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dc.contributor.authorKaneko, Yoshio Arturo
dc.contributor.authorKeshavan, Matcheri S
dc.date.accessioned2013-10-16T20:12:30Z
dc.date.issued2012
dc.identifier.citationKaneko, Yoshio, and Matcheri Keshavan. 2012. Cognitive remediation in schizophrenia. Clinical Psychopharmacology and Neuroscience 10(3): 125-135.en_US
dc.identifier.issn1738-1088en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11179842
dc.description.abstractCognitive deficits in schizophrenia are pervasive, severe, and largely independent of the positive and negative symptoms of the illness. These deficits are increasingly considered to be core features of schizophrenia with evidence that the extent of cognitive impairment is the most salient predictor of daily functioning. Unfortunately, current schizophrenia treatment has been limited in addressing the cognitive deficits of the illness. Alterations in neuroplasticity are hypothesized to underpin these cognitive deficits, though preserved neuroplasticity may offer an avenue towards cognitive remediation. Key neuroplastic principles to consider in designing remediation interventions include ensuring sufficient intensity and duration of remediation programs, "bottom-up" training that proceeds from simple to complex cognitive processes, and individual tailoring of remediation regimens. We discuss several cognitive remediation programs, including cognitive enhancement therapy, which embrace these principles to target neurocognitive and social cognitive improvements and which havebeen demonstrated to be effective in schizophrenia. Future directions in cognitive remediation research include potential synergy with pharmacologic treatment, non-invasive stimulation techniques, and psychosocial interventions, identification of patient characteristics that predict outcome with cognitive remediation, and increasing the access to these interventions in front-line settings.en_US
dc.language.isoen_USen_US
dc.publisherKorean College of Neuropsychopharmacologyen_US
dc.relation.isversionofdoi:10.9758/cpn.2012.10.3.125en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569160/pdf/en_US
dash.licenseLAA
dc.subjectSchizophreniaen_US
dc.subjectCognition disorders/pathologyen_US
dc.subjectCognition disorders/therapyen_US
dc.subjectCognition disorders/rehabilitationen_US
dc.subjectNeuronal plasticityen_US
dc.titleCognitive Remediation in Schizophreniaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalClinical Psychopharmacology and Neuroscienceen_US
dash.depositing.authorKeshavan, Matcheri S
dc.date.available2013-10-16T20:12:30Z
dc.identifier.doi10.9758/cpn.2012.10.3.125*
dash.contributor.affiliatedKaneko, Yoshio
dash.contributor.affiliatedKeshavan, Matcheri


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