Serum Lipid Profiles and Cancer Risk in the Context of Obesity: Four Meta-Analyses

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Serum Lipid Profiles and Cancer Risk in the Context of Obesity: Four Meta-Analyses

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Title: Serum Lipid Profiles and Cancer Risk in the Context of Obesity: Four Meta-Analyses
Author: Melvin, Jennifer C.; Holmberg, Lars; Rohrmann, Sabine; Loda, Massimo; Van Hemelrijck, Mieke

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Citation: Melvin, Jennifer C., Lars Holmberg, Sabine Rohrmann, Massimo Loda, and Mieke Van Hemelrijck. 2013. Serum lipid profiles and cancer risk in the context of obesity: four meta-analyses. Journal of Cancer Epidemiology 2013:823849.
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Abstract: The objective here was to summarize the evidence for, and quantify the link between, serum markers of lipid metabolism and risk of obesity-related cancers. PubMed and Embase were searched using predefined inclusion criteria to conduct meta-analyses on the association between serum levels of TG, TC, HDL, ApoA-I, and risk of 11 obesity-related cancers. Pooled relative risks (RRs) and 95% confidence intervals were estimated using random-effects analyses. 28 studies were included. Associations between abnormal lipid components and risk of obesity-related cancers when using clinical cutpoints (TC ≥ 6.50; TG ≥ 1.71; HDL ≤ 1.03; ApoA-I ≤ 1.05 mmol/L) were apparent in all models. RRs were 1.18 (95% CI: 1.08–1.29) for TC, 1.20 (1.07–1.35) for TG, 1.15 (1.01–1.32) for HDL, and 1.42 (1.17–1.74) for ApoA-I. High levels of TC and TG, as well as low levels of HDL and ApoA-I, were consistently associated with increased risk of obesity-related cancers. The modest RRs suggest serum lipids to be associated with the risk of cancer, but indicate it is likely that other markers of the metabolism and/or lifestyle factors may also be involved. Future intervention studies involving lifestyle modification would provide insight into the potential biological role of lipid metabolism in tumorigenesis.
Published Version: doi:10.1155/2013/823849
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563167/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11180368
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