Embryonic Origin and Remodeling of the Urinary and Digestive Outlets

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Embryonic Origin and Remodeling of the Urinary and Digestive Outlets

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Title: Embryonic Origin and Remodeling of the Urinary and Digestive Outlets
Author: Wang, Cheng-yen; Wang, Jingying; Borer, Joseph G.; Li, Xue

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Citation: Wang, Chen, JingYing Wang, Joseph G. Borer, and Xue Li. 2013. Embryonic origin and remodeling of the urinary and digestive outlets. PLoS ONE 8(2): e55587.
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Abstract: Separating digestive and urinary outlets is a critical step during mammalian embryogenesis. However, the natural history of these structures is poorly studied, and little is known about their embryonic origin. Here, we show that peri-cloacal mesenchymal (PCM) progenitors are the major source of these structures. Surprisingly, PCM progenitors also contribute to perineum, a structural barrier separating the urinary and digestive tracts, suggesting a potential role of PCM progenitors in establishing independent urinary and digestive outlets. We demonstrate that Six1 and Six2 are complementarily but asymmetrically expressed in the PCM progenitors. Deletion of these genes results in decreased cell survival and proliferation, and consequently in agenesis of the perineum and severe hypoplasia of the genital tubercle. Together, these findings suggest that PCM progenitors are the unexpected source of perineum and genital tubercle, and establish a basic framework for investigating normal and abnormal development of anorectal and genitourinary structures.
Published Version: doi:10.1371/journal.pone.0055587
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563631/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11180371
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