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dc.contributor.authorOken, Emily
dc.contributor.authorGuthrie, Lauren B
dc.contributor.authorBloomingdale, Arienne
dc.contributor.authorPlatek, Deborah Nehama
dc.contributor.authorPrice, Sarah
dc.contributor.authorHaines, Jess
dc.contributor.authorGillman, Matthew William
dc.contributor.authorOlsen, Sjurdur F.
dc.contributor.authorBellinger, David C.
dc.contributor.authorWright, Robert O.
dc.date.accessioned2013-10-17T13:37:33Z
dc.date.issued2013
dc.identifier.citationOken, Emily, Lauren B Guthrie, Arienne Bloomingdale, Deborah N Platek, Sarah Price, Jess Haines, Matthew W Gillman, Sjurdur F Olsen, David C Bellinger, and Robert O Wright. 2013. A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the food for thought study. Nutrition Journal 12: 33.en_US
dc.identifier.issn1475-2891en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11180386
dc.description.abstractBackground: Nutritionists advise pregnant women to eat fish to obtain adequate docosahexaenoic acid (DHA), an essential nutrient important for optimal brain development. However, concern exists that this advice will lead to excess intake of methylmercury, a developmental neurotoxicant. Objective: Conduct a pilot intervention to increase consumption of high-DHA, low-mercury fish in pregnancy. Methods: In April-October 2010 we recruited 61 women in the greater Boston, MA area at 12–22 weeks gestation who consumed <=2 fish servings/month, and obtained outcome data from 55. We randomized participants to 3 arms: Advice to consume low-mercury/high-DHA fish (n=18); Advice + grocery store gift cards (GC) to purchase fish (n=17); or Control messages (n=20). At baseline and 12-week follow-up we estimated intake of fish, DHA and mercury using a 1-month fish intake food frequency questionnaire, and measured plasma DHA and blood and hair total mercury. Results: Baseline characteristics and mean (range) intakes of fish [21 (0–125) g/day] and DHA from fish [91 (0–554) mg/d] were similar in all 3 arms. From baseline to follow-up, intake of fish [Advice: 12 g/day (95% CI: -5, 29), Advice+GC: 22 g/day (5, 39)] and DHA [Advice: 70 mg/d (3, 137), Advice+GC: 161 mg/d (93, 229)] increased in both intervention groups, compared with controls. At follow-up, no control women consumed >= 200mg/d of DHA from fish, compared with 33% in the Advice arm (p=0.005) and 53% in the Advice+GC arm (p=0.0002). We did not detect any differences in mercury intake or in biomarker levels of mercury and DHA between groups. Conclusions: An educational intervention increased consumption of fish and DHA but not mercury. Future studies are needed to determine intervention effects on pregnancy and childhood health outcomes. Trial registration Registered on clinicaltrials.gov as NCT01126762en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1475-2891-12-33en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616846/pdf/en_US
dash.licenseLAA
dc.subjectFishen_US
dc.subjectPregnancyen_US
dc.subjectNutritionen_US
dc.subjectMercuryen_US
dc.subjectOmega-3 fatty aciden_US
dc.subjectDocosahexaenoic acid (DHA)en_US
dc.titleA pilot randomized controlled trial to promote healthful fish consumption during pregnancy: The Food for Thought Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalNutrition Journalen_US
dash.depositing.authorOken, Emily
dc.date.available2013-10-17T13:37:33Z
dc.identifier.doi10.1186/1475-2891-12-33*
dash.contributor.affiliatedPlatek, Deborah Nehama
dash.contributor.affiliatedOlsen, Sjurdur
dash.contributor.affiliatedWright, Robert
dash.contributor.affiliatedOken, Emily
dash.contributor.affiliatedGillman, Matthew
dash.contributor.affiliatedBellinger, David
dc.identifier.orcid0000-0003-2513-3339


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