A Human Model of Small Fiber Neuropathy to Study Wound Healing

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A Human Model of Small Fiber Neuropathy to Study Wound Healing

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Title: A Human Model of Small Fiber Neuropathy to Study Wound Healing
Author: Illigens, Ben Min-Woo; Gibbons, Christopher H

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Citation: Illigens, Ben M. W., and Christopher H. Gibbons. 2013. A human model of small fiber neuropathy to study wound healing. PLoS ONE 8(1): e54760.
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Abstract: The aim of this study was to develop a human model of acute wound healing that isolated the effects of small fiber neuropathy on the healing process. Twenty-five healthy subjects had the transient receptor vanilloid 1 agonist capsaicin and placebo creams topically applied to contralateral areas on the skin of the thigh for 48 hours. Subjects had shallow (1.2 millimeter) and deep (>3 millimeter) punch skin biopsies from each thigh on days 1 and 14. Biopsy wound healing was monitored photographically until closure. Intra-epidermal and sweat-gland nerve fiber densities were measured for each biopsy. Shallow wounds in capsaicin-treated sites healed more slowly than in placebo treated skin with biopsies taken on day 1 (P<0.001) and day 14 (P<0.001). Deep biopsies in the capsaicin and placebo areas healed at similar rates at both time points. Nerve fiber densities were reduced only in capsaicin treated regions (P<0.01). In conclusion, topical application of capsaicin causes a small fiber neuropathy and is associated with a delay in healing of shallow, but not deep wounds. This novel human model may prove valuable in the study of wound healing in patients with neuropathy.
Published Version: doi:10.1371/journal.pone.0054760
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561391/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11180388
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