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dc.contributor.authorHuang, Hu
dc.contributor.authorKong, Dong
dc.contributor.authorByun, Kyung Hee
dc.contributor.authorYe, Chianping
dc.contributor.authorKoda, Shuichi
dc.contributor.authorLee, Dae Ho
dc.contributor.authorOh, Byung-Chul
dc.contributor.authorLee, Sam Whan
dc.contributor.authorLee, Bonghee
dc.contributor.authorZabolotny, Janice M.
dc.contributor.authorKim, Min Seon
dc.contributor.authorBjørbæk, Christian
dc.contributor.authorLowell, Bradford Barr
dc.contributor.authorKim, Young-Bum
dc.date.accessioned2013-10-17T13:42:22Z
dc.date.issued2012
dc.identifier.citationHuang, Hu, Dong Kong, Kyung Hee Byun, Chianping Ye, Shuichi Koda, Dae Ho Lee, Byung-Chul Oh, et al. 2012. Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling. Nature neuroscience 15(10): 1391-1398.en_US
dc.identifier.issn1097-6256en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11180389
dc.description.abstractLeptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. Here we report that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promotes the physical interaction of JAK2 and ROCK1, thereby increasing phosphorylation of JAK2 and downstream activation of Stat3 and FOXO1. Mice lacking ROCK1 in either POMC or AgRP neurons, mediators of leptin action, display obesity and impaired leptin sensitivity. In addition, deletion of ROCK1 in the arcuate nucleus markedly enhances food intake, resulting in severe obesity. Of note, ROCK1 is a specific mediator of leptin, but not insulin, regulation of POMC neuronal activity. Our data identify ROCK1 as a key regulator of leptin action on energy homeostasis.en_US
dc.language.isoen_USen_US
dc.relation.isversionofdoi:10.1038/nn.3207en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458121/pdf/en_US
dash.licenseLAA
dc.titleRho-kinase Regulates Energy Balance by Targeting Hypothalamic Leptin Receptor Signalingen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalNature neuroscienceen_US
dash.depositing.authorKim, Young-Bum
dc.date.available2013-10-17T13:42:22Z
dc.identifier.doi10.1038/nn.3207*
dash.authorsorderedfalse
dash.contributor.affiliatedHuang, Hu
dash.contributor.affiliatedKong, Dong
dash.contributor.affiliatedKim, Young-Bum
dash.contributor.affiliatedLee, Sam
dash.contributor.affiliatedZabolotny, Janice M.
dash.contributor.affiliatedLowell, Bradford


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