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dc.contributor.authorCserti-Gazdewich, Christine M.
dc.contributor.authorDhabangi, Aggrey
dc.contributor.authorMusoke, Charles
dc.contributor.authorSsewanyana, Isaac
dc.contributor.authorDdungu, Henry
dc.contributor.authorNakiboneka-Ssenabulya, Deborah
dc.contributor.authorNabukeera-Barungi, Nicolette
dc.contributor.authorMpimbaza, Arthur
dc.contributor.authorDzik, Walter Henry
dc.date.accessioned2013-10-17T14:27:08Z
dc.date.issued2013
dc.identifier.citationCserti-Gazdewich, Christine M., Aggrey Dhabangi, Charles Musoke, Isaac Ssewanyana, Henry Ddungu, Deborah Nakiboneka-Ssenabulya, Nicolette Nabukeera-Barungi, Arthur Mpimbaza, and Walter H. Dzik. 2013. Inter-relationships of cardinal features and outcomes of symptomatic pediatric plasmodium falciparum malaria in 1,933 children in kampala, uganda. The American Journal of Tropical Medicine and Hygiene 88(4): 747-756.en_US
dc.identifier.issn0002-9637en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11180456
dc.description.abstractMalaria remains a challenging diagnosis with variable clinical presentation and a wide spectrum of disease severity. Using a structured case report form, we prospectively assessed 1,933 children at Mulago Hospital in Kampala, Uganda with acute Plasmodium falciparum malaria. Children with uncomplicated malaria significantly differed from those with severe disease for 17 features. Among 855 children with severe disease, the case-fatality rate increased as the number of severity features increased. Logistic regression identified five factors independently associated with death: cerebral malaria, hypoxia, severe thrombocytopenia, leukocytosis, and lactic acidosis. Cluster analysis identified two groups: one combining anemia, splenomegaly, and leukocytosis; and a second group centered on death, severe thrombocytopenia, and lactic acidosis, which included cerebral malaria, hypoxia, hypoglycemia, and hyper-parasitemia. Our report updates previous clinical descriptions of severe malaria, quantifies significant clinical and laboratory inter-relationships, and will assist clinicians treating malaria and those planning or assessing future research (NCT00707200) (www.clinicaltrials.gov).en_US
dc.language.isoen_USen_US
dc.publisherThe American Society of Tropical Medicine and Hygieneen_US
dc.relation.isversionofdoi:10.4269/ajtmh.12-0668en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617864/pdf/en_US
dash.licenseLAA
dc.titleInter-Relationships of Cardinal Features and Outcomes of Symptomatic Pediatric Plasmodium falciparum Malaria in 1,933 Children in Kampala, Ugandaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalThe American Journal of Tropical Medicine and Hygieneen_US
dash.depositing.authorDzik, Walter Henry
dc.date.available2013-10-17T14:27:08Z
dc.identifier.doi10.4269/ajtmh.12-0668*
dash.contributor.affiliatedDzik, Walter


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