PBAT: A comprehensive software package for genome-wide association analysis of complex family-based studies
Van Steen, Kristel
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CitationVan Steen, Kristel, and Christoph Lange. 2005. Pbat: a comprehensive software package for genome-wide association analysis of complex family-based studies. Human Genomics 2(1): 67-69.
AbstractThe PBAT software package (v2.5) provides a unique set of tools for complex family-based association analysis at a genome-wide level. PBAT can handle nuclear families with missing parental genotypes, extended pedigrees with missing genotypic information, analysis of single nucleotide polymorphisms (SNPs), haplotype analysis, quantitative traits, multivariate/longitudinal data and time to onset phenotypes. The data analysis can be adjusted for covariates and gene/environment interactions. Haplotype-based features include sliding windows and the reconstruction of the haplotypes of the probands. PBAT's screening tools allow the user successfully to handle the multiple comparisons problem at a genome-wide level, even for 100,000 SNPs and more. Moreover, PBAT is computationally fast. A genome scan of 300,000 SNPs in 2,000 trios takes 4 central processing unit (CPU)-days. PBAT is available for Linux, Sun Solaris and Windows XP.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11180464