PBAT: A comprehensive software package for genome-wide association analysis of complex family-based studies

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PBAT: A comprehensive software package for genome-wide association analysis of complex family-based studies

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Title: PBAT: A comprehensive software package for genome-wide association analysis of complex family-based studies
Author: Van Steen, Kristel; Lange, Christoph

Note: Order does not necessarily reflect citation order of authors.

Citation: Van Steen, Kristel, and Christoph Lange. 2005. Pbat: a comprehensive software package for genome-wide association analysis of complex family-based studies. Human Genomics 2(1): 67-69.
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Abstract: The PBAT software package (v2.5) provides a unique set of tools for complex family-based association analysis at a genome-wide level. PBAT can handle nuclear families with missing parental genotypes, extended pedigrees with missing genotypic information, analysis of single nucleotide polymorphisms (SNPs), haplotype analysis, quantitative traits, multivariate/longitudinal data and time to onset phenotypes. The data analysis can be adjusted for covariates and gene/environment interactions. Haplotype-based features include sliding windows and the reconstruction of the haplotypes of the probands. PBAT's screening tools allow the user successfully to handle the multiple comparisons problem at a genome-wide level, even for 100,000 SNPs and more. Moreover, PBAT is computationally fast. A genome scan of 300,000 SNPs in 2,000 trios takes 4 central processing unit (CPU)-days. PBAT is available for Linux, Sun Solaris and Windows XP.
Published Version: doi:10.1186/1479-7364-2-1-67
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525120/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11180464
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