Show simple item record

dc.contributor.authorVan Steen, Kristel
dc.contributor.authorLange, Christoph
dc.date.accessioned2013-10-17T14:40:32Z
dc.date.issued2005
dc.identifier.citationVan Steen, Kristel, and Christoph Lange. 2005. Pbat: a comprehensive software package for genome-wide association analysis of complex family-based studies. Human Genomics 2(1): 67-69.en_US
dc.identifier.issn1473-9542en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11180464
dc.description.abstractThe PBAT software package (v2.5) provides a unique set of tools for complex family-based association analysis at a genome-wide level. PBAT can handle nuclear families with missing parental genotypes, extended pedigrees with missing genotypic information, analysis of single nucleotide polymorphisms (SNPs), haplotype analysis, quantitative traits, multivariate/longitudinal data and time to onset phenotypes. The data analysis can be adjusted for covariates and gene/environment interactions. Haplotype-based features include sliding windows and the reconstruction of the haplotypes of the probands. PBAT's screening tools allow the user successfully to handle the multiple comparisons problem at a genome-wide level, even for 100,000 SNPs and more. Moreover, PBAT is computationally fast. A genome scan of 300,000 SNPs in 2,000 trios takes 4 central processing unit (CPU)-days. PBAT is available for Linux, Sun Solaris and Windows XP.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1479-7364-2-1-67en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525120/pdf/en_US
dash.licenseLAA
dc.subjectassociation analysisen_US
dc.subjectextended pedigreesen_US
dc.subjectgenome-wide screeningen_US
dc.subjectquantitative and qualitative traitsen_US
dc.subjecthaplotypesen_US
dc.titlePBAT: A comprehensive software package for genome-wide association analysis of complex family-based studiesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalHuman Genomicsen_US
dash.depositing.authorLange, Christoph
dc.date.available2013-10-17T14:40:32Z
dc.identifier.doi10.1186/1479-7364-2-1-67*
dash.contributor.affiliatedLange, Christoph


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record