Induction and molecular signature of pathogenic TH17 cells

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Induction and molecular signature of pathogenic TH17 cells

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Title: Induction and molecular signature of pathogenic TH17 cells
Author: Lee, Youjin; Awasthi, Amit; Yosef, Nir; Quintana, Francisco Javier; Xiao, Sheng; Peters, Anneli; Wu, Chuan; Kleinewietfeld, Markus; Kunder, Sharon R.; Hafler, David A.; Sobel, Raymond A.; Regev, Aviv; Kuchroo, Vijay Kumar

Note: Order does not necessarily reflect citation order of authors.

Citation: Lee, Youjin, Amit Awasthi, Nir Yosef, Francisco J. Quintana, Sheng Xiao, Anneli Peters, Chuan Wu, et al. 2012. Induction and molecular signature of pathogenic th17 cells. Nature immunology 13(10): 991-999.
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Abstract: Interleukin 17 (IL-17)-producing TH17 cells are often present at the sites of tissue inflammation in autoimmune diseases, which has lead to the conclusion that TH17 are main drivers of autoimmune tissue injury. However, not all TH17 cells are pathogenic, in fact TH17 generated with TGF-β1 and IL-6 produce IL-17 but do not readily induce autoimmune disease without further exposure to IL-23. Here we show that TGF-β3, produced by developing TH17 cells, is dependent on IL-23, which together with IL-6 induces highly pathogenic TH17 cells. Moreover, TGF-β3-induced TH17 cells are functionally and molecularly distinct from TGF-β1-induced TH17 cells and possess a molecular signature that defines pathogenic effector TH17 cells in autoimmune disease.
Published Version: doi:10.1038/ni.2416
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459594/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11180466
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