Show simple item record

dc.contributor.authorSong, Fengju
dc.contributor.authorQureshi, Abrar A.
dc.contributor.authorGiovannucci, Edward L.
dc.contributor.authorFuchs, Charles Stewart
dc.contributor.authorChen, Wendy Yvonne
dc.contributor.authorStampfer, Meir
dc.contributor.authorHan, Jiali
dc.date.accessioned2013-10-17T16:39:22Z
dc.date.issued2013
dc.identifier.citationSong, Fengju, Abrar A. Qureshi, Edward L. Giovannucci, Charlie S. Fuchs, Wendy Y. Chen, Meir J. Stampfer, and Jiali Han. 2013. Risk of a second primary cancer after non-melanoma skin cancer in white men and women: a prospective cohort study. PLoS Medicine 10(4): e1001433.en_US
dc.identifier.issn1549-1277en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11180989
dc.description.abstractBackground: Previous studies suggest a positive association between history of non-melanoma skin cancer (NMSC) and risk of subsequent cancer at other sites. The purpose of this study is to prospectively examine the risk of primary cancer according to personal history of NMSC. Methods and Findings: In two large US cohorts, the Health Professionals Follow-up Study (HPFS) and the Nurses' Health Study (NHS), we prospectively investigated this association in self-identified white men and women. In the HPFS, we followed 46,237 men from June 1986 to June 2008 (833,496 person-years). In the NHS, we followed 107,339 women from June 1984 to June 2008 (2,116,178 person-years). We documented 29,447 incident cancer cases other than NMSC. Cox proportional hazard models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs). A personal history of NMSC was significantly associated with a higher risk of other primary cancers excluding melanoma in men (RR = 1.11; 95% CI 1.05–1.18), and in women (RR = 1.20; 95% CI 1.15–1.25). Age-standardized absolute risk (AR) was 176 in men and 182 in women per 100,000 person-years. For individual cancer sites, after the Bonferroni correction for multiple comparisons (n = 28), in men, a personal history of NMSC was significantly associated with an increased risk of melanoma (RR = 1.99, AR = 116 per 100,000 person-years). In women, a personal history of NMSC was significantly associated with an increased risk of breast (RR = 1.19, AR = 87 per 100,000 person-years), lung (RR = 1.32, AR = 22 per 100,000 person-years), and melanoma (RR = 2.58, AR = 79 per 100,000 person-years). Conclusion: This prospective study found a modestly increased risk of subsequent malignancies among individuals with a history of NMSC, specifically breast and lung cancer in women and melanoma in both men and women. Please see later in the article for the Editors' Summaryen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pmed.1001433en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635863/pdf/en_US
dash.licenseLAA
dc.subjectMedicineen_US
dc.subjectEpidemiologyen_US
dc.subjectCancer Epidemiologyen_US
dc.subjectOncologyen_US
dc.titleRisk of a Second Primary Cancer after Non-melanoma Skin Cancer in White Men and Women: A Prospective Cohort Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Medicineen_US
dash.depositing.authorHan, Jiali
dc.date.available2013-10-17T16:39:22Z
dc.identifier.doi10.1371/journal.pmed.1001433*
dash.contributor.affiliatedChen, Wendy
dash.contributor.affiliatedSong, F
dash.contributor.affiliatedHan, Jiali
dash.contributor.affiliatedGiovannucci, Edward
dash.contributor.affiliatedStampfer, Meir
dash.contributor.affiliatedFuchs, Charles


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record