Mannose-Binding Lectin 2 Gene and Risk of Adult Glioma

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Mannose-Binding Lectin 2 Gene and Risk of Adult Glioma

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Title: Mannose-Binding Lectin 2 Gene and Risk of Adult Glioma
Author: Michaud, Dominique S.; Siddiq, Afshan; Cox, David G.; Backes, Danielle M.; Calboli, Federico C. F.; Sughrue, Michael E.; Gaziano, John Michael; Ma, Jing; Stampfer, Meir Jonathan; Tworoger, Shelley Slate; Hunter, David J.; Camargo, Carlos Arturo; Parsa, Andrew T.

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Citation: Michaud, Dominique S., Afshan Siddiq, David G. Cox, Danielle M. Backes, Federico C. F. Calboli, Michael E. Sughrue, J. Michael Gaziano, et al. 2013. Mannose-binding lectin 2 gene and risk of adult glioma. PLoS ONE 8(4): e61117.
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Abstract: Background and Aims The immune system is likely to play a key role in the etiology of gliomas. Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lectin complement pathway, have been associated with risk of several cancers. Methods: To examine the role of the lectin complement pathway, we combined data from prospectively collected cohorts with available DNA specimens. Using a nested case-control design, we genotyped 85 single nucleotide polymorphisms (SNPs) in 9 genes in the lectin complement pathway and 3 additional SNPs in MBL2 were tested post hoc). Initial SNPs were selected using tagging SNPs for haplotypes; the second group of SNPs for MBL2 was selected based on functional SNPs related to phenotype. Associations were examined using logistic regression analysis. All statistical tests were two-sided. Nominal p-values are presented and are not corrected for multiple comparisons. Results: A total of 143 glioma cases and 419 controls were available for this analysis. Statistically significant associations were observed for two SNPs in the mannose-binding lectin 2 (ML2) gene and risk of glioma (rs1982266 and rs1800450, test for trend p = 0.003 and p = 0.04, respectively, using the additive model). One of these SNPs, rs1800450, was associated with a 58% increase in glioma risk among those carrying one or two mutated alleles (odds ratio = 1.58, 95% confidence interval = 0.99–2.54), compared to those homozygous for the wild type allele. Conclusions: Overall, our findings suggest that MBL may play a role in the etiology of glioma. Future studies are needed to confirm these findings which may be due to chance, and if reproduced, to determine mechanisms that link glioma pathogenesis with the MBL complement pathway.
Published Version: doi:10.1371/journal.pone.0061117
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630225/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181007
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