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dc.contributor.authorShaheen, Shagufta
dc.contributor.authorGuddati, Achuta K
dc.date.accessioned2013-10-17T19:04:24Z
dc.date.issued2013
dc.identifier.citationShaheen, Shagufta, and Achuta K. Guddati. 2013. Gastrointestinal stromal tumor: a rare abdominal tumor. Case Reports in Oncology 6(1): 148-153.en_US
dc.identifier.issn1662-6575en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11181010
dc.description.abstractGastrointestinal stromal tumors (GISTs) are rare abdominal tumors which arise from the interstitial cells of Cajal in the gastrointestinal tract. Gastric GISTs are the most commonly seen GIST tumors and may grow to a very large size. They are often associated with abdominal pain, anorexia and weight loss. Most of them can be detected by CT. These tumors have been found to harbor mutations in CD117 which causes constitutional activation of the tyrosine kinase signaling pathway and is considered to be pathognomic. Tyrosine kinase inhibitors such as imatinib have revolutionized the treatment of these tumors, which are otherwise resistant to conventional chemotherapy and radiotherapy. Although surgical resection is the mainstay of treatment, tyrosine kinase inhibitors have been useful in prolonging the recurrence-free survival of these patients. Resistance to imatinib has been reported in GISTs with specific mutations. We present a case of gastric GIST which grew to a very large size and was associated with abdominal pain and weight loss. It was successfully resected and the patient was commenced on imatinib therapy.en_US
dc.language.isoen_USen_US
dc.publisherS. Karger AGen_US
dc.relation.isversionofdoi:10.1159/000350061en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618098/pdf/en_US
dash.licenseLAA
dc.subjectGastrointestinal stromal tumoren_US
dc.subjectAbdominal tumoren_US
dc.subjectCD117en_US
dc.subjectRare tumoren_US
dc.subjectSizeen_US
dc.subjectGastric tumoren_US
dc.titleGastrointestinal Stromal Tumor: A Rare Abdominal Tumoren_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalCase Reports in Oncologyen_US
dash.depositing.authorGuddati, Achuta K
dc.date.available2013-10-17T19:04:24Z
dc.identifier.doi10.1159/000350061*
dash.contributor.affiliatedShaheen, Shagufta
dash.contributor.affiliatedGuddati, Achuta K


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