No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
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Author
Scott, Robert A.
Grarup, Niels
Manning, Alisa K.
Hivert, Marie-France
Shungin, Dmitry
Tönjes, Anke
Yesupriya, Ajay
Barnes, Daniel
Bouatia-Naji, Nabila
Glazer, Nicole L.
Jackson, Anne U.
Kutalik, Zoltán
Lagou, Vasiliki
Marek, Diana
Rasmussen-Torvik, Laura J.
Stringham, Heather M.
Tanaka, Toshiko
Aadahl, Mette
Arking, Dan E.
Bergmann, Sven
Boerwinkle, Eric
Bonnycastle, Lori L.
Bornstein, Stefan R.
Brunner, Eric
Bumpstead, Suzannah J.
Brage, Soren
Carlson, Olga D.
Chen, Han
Chen, Yii-Der Ida
Chines, Peter S.
Collins, Francis S.
Couper, David J.
Dennison, Elaine M.
Dowling, Nicole F.
Egan, Josephine S.
Ekelund, Ulf
Erdos, Michael R.
Forouhi, Nita G.
Goodarzi, Mark O.
Grässler, Jürgen
Gustafsson, Stefan
Hallmans, Göran
Hansen, Torben
Hingorani, Aroon
Holloway, John W.
Isomaa, Bo
Jameson, Karen A.
Johansson, Ingegerd
Jonsson, Anna
Jørgensen, Torben
Kivimaki, Mika
Kovacs, Peter
Kumari, Meena
Kuusisto, Johanna
Laakso, Markku
Lecoeur, Cécile
Lévy-Marchal, Claire
Li, Guo
Loos, Ruth J.F.
Lyssenko, Valeri
Marmot, Michael
Marques-Vidal, Pedro
Morken, Mario A.
Müller, Gabriele
North, Kari E.
Pankow, James S.
Payne, Felicity
Prokopenko, Inga
Psaty, Bruce M.
Renström, Frida
Rice, Ken
Rotter, Jerome I.
Rybin, Denis
Sandholt, Camilla H.
Sayer, Avan A.
Shrader, Peter
Schwarz, Peter E.H.
Siscovick, David S.
Stančáková, Alena
Stumvoll, Michael
Teslovich, Tanya M.
Waeber, Gérard
Witte, Daniel R.
Wood, Andrew R.
Xie, Weijia
Boehnke, Michael
Cooper, Cyrus
Ferrucci, Luigi
Froguel, Philippe
Groop, Leif
Kao, W.H. Linda
Vollenweider, Peter
Walker, Mark
Watanabe, Richard M.
Pedersen, Oluf
Ingelsson, Erik
Barroso, Inês
Franks, Paul W.
Dupuis, Josée
Wareham, Nicholas J.
Langenberg, Claudia
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.2337/db11-0973Metadata
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Scott, Robert A., Audrey Y. Chu, Niels Grarup, Alisa K. Manning, Marie-France Hivert, Dmitry Shungin, Anke Tönjes, et al. 2012. No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes 61(5): 1291-1296.Abstract
Gene–lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13–0.31], P = 1.63 × 10−6). All SNPs were associated with 2-h glucose (β = 0.06–0.12 mmol/allele, P ≤ 1.53 × 10−7), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene–lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331745/pdf/Terms of Use
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