Titanium-Tethered Vancomycin Prevents Resistance to Rifampicin in Staphylococcus Aureus in Vitro

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Titanium-Tethered Vancomycin Prevents Resistance to Rifampicin in Staphylococcus Aureus in Vitro

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Title: Titanium-Tethered Vancomycin Prevents Resistance to Rifampicin in Staphylococcus Aureus in Vitro
Author: Rottman, Martin; Goldberg, Joel Edward; Hacking, S. Adam

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Citation: Rottman, Martin, Joel Goldberg, and S. Adam Hacking. 2012. Titanium-tethered vancomycin prevents resistance to rifampicin in staphylococcus aureus in vitro. PLoS ONE 7(12): e52883.
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Abstract: Rifampicin is currently recognized as the most potent drug against Gram positive implant related infections. The use of rifampicin is limited by the emergence of bacterial resistance, which is often managed by coadministration of a second antibiotic. The purpose of this study was to determine the effectiveness of soluble rifampicin in combination with vancomycin tethered to titanium metal as a means to control bacterial growth and resistance in vitro. Bacterial growth was inhibited when the vancomycin-tethered titanium discs were treated with Staphylococcus aureus inocula of \(≤2×10^6\) CFU, however inocula greater than \(2×10^6\) CFU/disc adhered and survived. The combination of surface-tethered vancomycin with soluble rifampicin enhanced the inhibitory effect of rifampicin for an inoculum of \(10^6 CFU/cm^2\) by one dilution (combination MIC of 0.008 mg/L versus 0.015 mg/L for rifampicin alone). Moreover, surface tethered vancomycin prevented the emergence of a rifampicin resistant population in an inoculum of \(2×10^8\) CFU.
Published Version: doi:10.1371/journal.pone.0052883
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527614/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181027
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