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dc.contributor.authorZürcher, Nicole R.
dc.contributor.authorDonnelly, Nick
dc.contributor.authorRogier, Ophélie
dc.contributor.authorRusso, Britt
dc.contributor.authorHippolyte, Loyse
dc.contributor.authorHadwin, Julie
dc.contributor.authorLemonnier, Eric
dc.contributor.authorHadjikhani, Nouchine
dc.date.accessioned2013-10-17T19:45:50Z
dc.date.issued2013
dc.identifier.citationZürcher, Nicole R., Nick Donnelly, Ophélie Rogier, Britt Russo, Loyse Hippolyte, Julie Hadwin, Eric Lemonnier, and Nouchine Hadjikhani. 2013. It’s all in the eyes: subcortical and cortical activation during grotesqueness perception in autism. PLoS ONE 8(1): e54313.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11181041
dc.description.abstractAtypical face processing plays a key role in social interaction difficulties encountered by individuals with autism. In the current fMRI study, the Thatcher illusion was used to investigate several aspects of face processing in 20 young adults with high-functioning autism spectrum disorder (ASD) and 20 matched neurotypical controls. “Thatcherized” stimuli were modified at either the eyes or the mouth and participants discriminated between pairs of faces while cued to attend to either of these features in upright and inverted orientation. Behavioral data confirmed sensitivity to the illusion and intact configural processing in ASD. Directing attention towards the eyes vs. the mouth in upright faces in ASD led to (1) improved discrimination accuracy; (2) increased activation in areas involved in social and emotional processing; (3) increased activation in subcortical face-processing areas. Our findings show that when explicitly cued to attend to the eyes, activation of cortical areas involved in face processing, including its social and emotional aspects, can be enhanced in autism. This suggests that impairments in face processing in autism may be caused by a deficit in social attention, and that giving specific cues to attend to the eye-region when performing behavioral therapies aimed at improving social skills may result in a better outcome.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0054313en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544832/pdf/en_US
dash.licenseLAA
dc.subjectMedicineen_US
dc.subjectMental Healthen_US
dc.subjectPsychiatryen_US
dc.subjectNeuropsychiatric Disordersen_US
dc.subjectPsychologyen_US
dc.subjectClinical Psychologyen_US
dc.subjectNeurologyen_US
dc.subjectCognitive Neurologyen_US
dc.subjectNeuroimagingen_US
dc.subjectSocial and Behavioral Sciencesen_US
dc.subjectBehavioren_US
dc.subjectEmotionsen_US
dc.subjectSensory Perceptionen_US
dc.subjectSocial Psychologyen_US
dc.titleIt’s All in the Eyes: Subcortical and Cortical Activation During Grotesqueness Perception in Autismen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorHadjikhani, Nouchine
dc.date.available2013-10-17T19:45:50Z
dc.identifier.doi10.1371/journal.pone.0054313*
dash.contributor.affiliatedHadjikhani, Nouchine


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