dc.contributor.author | Felio, Kyrie | |
dc.contributor.author | Nguyen, Hanh | |
dc.contributor.author | Dascher, Christopher C. | |
dc.contributor.author | Choi, Hak-Jong | |
dc.contributor.author | Li, Sha | |
dc.contributor.author | Zimmer, Michael I. | |
dc.contributor.author | Colmone, Angela | |
dc.contributor.author | Moody, D Branch | |
dc.contributor.author | Brenner, Michael Barry | |
dc.contributor.author | Wang, Chyung-Ru | |
dc.date.accessioned | 2013-10-17T21:44:52Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Felio, Kyrie, Hanh Nguyen, Christopher C. Dascher, Hak-Jong Choi, Sha Li, Michael I. Zimmer, Angela Colmone, D. Branch Moody, Michael B. Brenner, and Chyung-Ru Wang. 2009. CD1-restricted adaptive immune responses to in human group 1 CD1 transgenic mice. Journal of Experimental Medicine 206(11): 2497-2509. | en_US |
dc.identifier.issn | 0022-1007 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181056 | |
dc.description.abstract | Group 1 CD1 (CD1a, CD1b, and CD1c)–restricted T cells recognize mycobacterial lipid antigens and are found at higher frequencies in Mycobacterium tuberculosis (Mtb)–infected individuals. However, their role and dynamics during infection remain unknown because of the lack of a suitable small animal model. We have generated human group 1 CD1 transgenic (hCD1Tg) mice that express all three human group 1 CD1 isoforms and support the development of group 1 CD1–restricted T cells with diverse T cell receptor usage. Both mycobacterial infection and immunization with Mtb lipids elicit group 1 CD1–restricted Mtb lipid–specific T cell responses in hCD1Tg mice. In contrast to CD1d-restricted NKT cells, which rapidly respond to initial stimulation but exhibit anergy upon reexposure, group 1 CD1–restricted T cells exhibit delayed primary responses and more rapid secondary responses, similar to conventional T cells. Collectively, our data demonstrate that group 1 CD1–restricted T cells participate in adaptive immune responses upon mycobacterial infection and could serve as targets for the development of novel Mtb vaccines. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Rockefeller University Press | en_US |
dc.relation.isversionof | doi:10.1084/jem.20090898 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768849/pdf/ | en_US |
dash.license | LAA | |
dc.title | CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Journal of Experimental Medicine | en_US |
dash.depositing.author | Brenner, Michael Barry | |
dc.date.available | 2013-10-17T21:44:52Z | |
dc.identifier.doi | 10.1084/jem.20090898 | * |
dash.contributor.affiliated | Moody, David | |
dash.contributor.affiliated | Brenner, Michael | |