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dc.contributor.authorRobinson, Christopher
dc.contributor.authorSingh, Gurdeep
dc.contributor.authorLee, Jeong Yoon
dc.contributor.authorDehghan, Shoaleh
dc.contributor.authorRajaiya, Jaya
dc.contributor.authorLiu, Elizabeth B.
dc.contributor.authorYousuf, Mohammad Abu
dc.contributor.authorBetensky, Rebecca Aubrey
dc.contributor.authorJones, Morris S.
dc.contributor.authorDyer, David W.
dc.contributor.authorSeto, Donald
dc.contributor.authorChodosh, James
dc.date.accessioned2013-10-18T12:28:44Z
dc.date.issued2013
dc.identifier.citationRobinson, Christopher M., Gurdeep Singh, Jeong Yoon Lee, Shoaleh Dehghan, Jaya Rajaiya, Elizabeth B. Liu, Mohammad A. Yousuf, et al. 2013. Molecular evolution of human adenoviruses. Scientific Reports 3:1812.en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11181087
dc.description.abstractThe recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the previously unsequenced HAdV serotypes (n = 20) within HAdV species D. Analysis of nucleotide sequence variability for these in conjunction with another 40 HAdV prototypes, comprising all seven HAdV species, confirmed the uniquely hypervariable regions within species. The mutation rate among HAdV-Ds was low when compared to other HAdV species. Homologous recombination was identified in at least two of five examined hypervariable regions for every virus, suggesting the evolution of HAdV-Ds has been highly dependent on homologous recombination. Patterns of alternating GC and AT rich motifs correlated well with hypervariable region recombination sites across the HAdV-D genomes, suggesting foci of DNA instability lead to formulaic patterns of homologous recombination and confer agility to adenovirus evolution.en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/srep01812en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648800/pdf/en_US
dash.licenseLAA
dc.titleMolecular evolution of human adenovirusesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalScientific Reportsen_US
dash.depositing.authorChodosh, James
dc.date.available2013-10-18T12:28:44Z
dc.identifier.doi10.1038/srep01812*
dash.authorsorderedfalse
dash.contributor.affiliatedRajaiya, Jaya
dash.contributor.affiliatedRobinson, Christopher
dash.contributor.affiliatedLee, Jeong Yoon
dash.contributor.affiliatedSingh, Gurdeep
dash.contributor.affiliatedBetensky, Rebecca
dash.contributor.affiliatedYousuf, Mohammad Abu
dash.contributor.affiliatedChodosh, James


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