Differential regulation of neurexin at glutamatergic and GABAergic synapses

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Differential regulation of neurexin at glutamatergic and GABAergic synapses

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Title: Differential regulation of neurexin at glutamatergic and GABAergic synapses
Author: Pregno, Giulia; Frola, Elena; Graziano, Stefania; Patrizi, Annarita; Bussolino, Federico; Arese, Marco; Sassoè-Pognetto, Marco

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Citation: Pregno, Giulia, Elena Frola, Stefania Graziano, Annarita Patrizi, Federico Bussolino, Marco Arese, and Marco Sassoè-Pognetto. 2013. Differential regulation of neurexin at glutamatergic and gabaergic synapses. Frontiers in Cellular Neuroscience 7:35.
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Abstract: Neurexins (Nrxs) have emerged as potential determinants of synaptic specificity, but little is known about their localization at central synapses. Here we show that Nrxs have a remarkably selective localization at distinct types of glutamatergic synapses and we reveal an unexpected ontogenetic regulation of Nrx expression at GABAergic synapses. Our data indicate that synapses are specified by molecular interactions that involve both Nrx-dependent and Nrx-independent mechanisms. We propose that differences in the spatio-temporal profile of Nrx expression may contribute to specify the molecular identity of synapses.
Published Version: doi:10.3389/fncel.2013.00035
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616244/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181091
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