Differential regulation of neurexin at glutamatergic and GABAergic synapses

View/ Open
Author
Pregno, Giulia
Frola, Elena
Graziano, Stefania
Bussolino, Federico
Arese, Marco
Sassoè-Pognetto, Marco
Published Version
https://doi.org/10.3389/fncel.2013.00035Metadata
Show full item recordCitation
Pregno, Giulia, Elena Frola, Stefania Graziano, Annarita Patrizi, Federico Bussolino, Marco Arese, and Marco Sassoè-Pognetto. 2013. Differential regulation of neurexin at glutamatergic and gabaergic synapses. Frontiers in Cellular Neuroscience 7:35.Abstract
Neurexins (Nrxs) have emerged as potential determinants of synaptic specificity, but little is known about their localization at central synapses. Here we show that Nrxs have a remarkably selective localization at distinct types of glutamatergic synapses and we reveal an unexpected ontogenetic regulation of Nrx expression at GABAergic synapses. Our data indicate that synapses are specified by molecular interactions that involve both Nrx-dependent and Nrx-independent mechanisms. We propose that differences in the spatio-temporal profile of Nrx expression may contribute to specify the molecular identity of synapses.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616244/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181091
Collections
- HMS Scholarly Articles [17875]
Contact administrator regarding this item (to report mistakes or request changes)