DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy

 
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Xiao, Zeyu
Pridgen, Eric M
Frieder, Jillian
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https://doi.org/10.1002/anie.201204018
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Xiao, Zeyu, Changwei Ji, Jinjun Shi, Eric M Pridgen, Jillian Frieder, Jun Wu, and Omid C Farokhzad. 2012. DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angewandte Chemie International Edition 51(47): 11853-11857.
Abstract
Targeted Cancer Therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy in vitro and in vivo.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532659/pdf/
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181093

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