Turning Oscillations into Opportunities: Lessons from a Bacterial Decision Gate

DSpace/Manakin Repository

Turning Oscillations into Opportunities: Lessons from a Bacterial Decision Gate

Citable link to this page

 

 
Title: Turning Oscillations into Opportunities: Lessons from a Bacterial Decision Gate
Author: Schultz, Daniel; Lu, Mingyang; Stavropoulos, Trevor; Onuchic, Jose; Ben-Jacob, Eshel

Note: Order does not necessarily reflect citation order of authors.

Citation: Schultz, Daniel, Mingyang Lu, Trevor Stavropoulos, Jose Onuchic, and Eshel Ben-Jacob. 2013. Turning oscillations into opportunities: lessons from a bacterial decision gate. Scientific Reports 3:1668.
Full Text & Related Files:
Abstract: Sporulation vs. competence provides a prototypic example of collective cell fate determination. The decision is performed by the action of three modules: 1) A stochastic competence switch whose transition probability is regulated by population density, population stress and cell stress. 2) A sporulation timer whose clock rate is regulated by cell stress and population stress. 3) A decision gate that is coupled to the timer via a special repressilator-like loop. We show that the distinct circuit architecture of this gate leads to special dynamics and noise management characteristics: The gate opens a time-window of opportunity for competence transitions during which it generates oscillations that are turned into a chain of transition opportunities – each oscillation opens a short interval with high transition probability. The special architecture of the gate also leads to filtering of external noise and robustness against internal noise and variations in the circuit parameters.
Published Version: doi:10.1038/srep01668
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627974/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181097
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters