Harnessing Evolutionary Fitness in Plasmodium falciparum for Drug Discovery and Suppressing Resistance

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Harnessing Evolutionary Fitness in Plasmodium falciparum for Drug Discovery and Suppressing Resistance

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Title: Harnessing Evolutionary Fitness in Plasmodium falciparum for Drug Discovery and Suppressing Resistance
Author: Ross, Leila Saxby
Citation: Ross, Leila Saxby. 2013. Harnessing Evolutionary Fitness in Plasmodium falciparum for Drug Discovery and Suppressing Resistance. Doctoral dissertation, Harvard University.
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Abstract: Malaria is a preventable and treatable disease caused by infection with Plasmodium parasites. Complex socioeconomic and political factors limit access to vector control and antimalarial drugs, and an estimated 600,000 people die from malaria every year. Rising drug resistance threatens to make malaria untreatable. As for all new traits, resistance is limited by fitness, and a small number of pathways are heavily favored by evolution. These pathways are targets for drug discovery. Pairing compounds active against the wild-type and the small emerging resistant population, a strategy we termed "targeting resistance," could block the rise of competitively viable resistance.
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181104
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