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dc.contributor.advisorFontana, Walter
dc.contributor.advisorMitchison, Timothy J.
dc.contributor.authorRomero, Catalina
dc.date.accessioned2013-10-18T13:41:01Z
dash.embargo.terms2015-10-10en_US
dash.embargo.terms2015-10-10
dc.date.issued2013-10-18
dc.date.submitted2013
dc.identifier.citationRomero, Catalina. 2013. Spatio-temporal control of the cytosolic redox environment in C. elegans. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:11122en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11181131
dc.description.abstractCompartmentalization of redox reactions is essential to all life forms. Protein activity can respond to changes in the local redox environment through the reversible oxidation of cysteine thiols. For the majority of cysteines in the proteome, this interaction takes place through equilibration with the glutathione pool; this raises the question whether this redox pool acts as a buffer, or instead as a sensitive media, transducing information from a local physiological state into protein function.en_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectMolecular biologyen_US
dc.subjectCellular biologyen_US
dc.subjectGeneticsen_US
dc.subjectagingen_US
dc.subjectC. elegansen_US
dc.subjectinsulin signalingen_US
dc.subjectoxidation reduction of proteinsen_US
dc.subjectredox potential of glutathione (GSH)en_US
dc.subjectspatial patterningen_US
dc.titleSpatio-temporal control of the cytosolic redox environment in C. elegansen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorRomero, Catalina
dc.date.available2015-10-10T07:32:59Z
thesis.degree.date2013en_US
thesis.degree.disciplineSystems Biologyen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberMitchison, Timothyen_US
dc.contributor.committeeMemberDePace, Angelaen_US
dc.contributor.committeeMemberNeedleman, Danielen_US
dash.contributor.affiliatedRomero, Catalina


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