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dc.contributor.authorKwon, Young-Min
dc.contributor.authorMellon, S. J.
dc.contributor.authorMonk, P.
dc.contributor.authorMurray, D. W.
dc.contributor.authorGill, H. S.
dc.date.accessioned2013-10-18T13:58:43Z
dc.date.issued2012
dc.identifier.citationKwon, Y-M., S. J. Mellon, P. Monk, D. W. Murray, and H. S. Gill. 2012. In vivo evaluation of edge-loading in metal-on-metal hip resurfacing patients with pseudotumours. Bone & Joint Research 1(4): 42-49.en_US
dc.identifier.issn2046-3758en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11181170
dc.description.abstractObjectives: Pseudotumours (abnormal peri-prosthetic soft-tissue reactions) following metal-on-metal hip resurfacing arthroplasty (MoMHRA) have been associated with elevated metal ion levels, suggesting that excessive wear may occur due to edge-loading of these MoM implants. This study aimed to quantify in vivo edge-loading in MoMHRA patients with and without pseudotumours during functional activities. Methods: The duration and magnitude of edge-loading in vivo was quantified during functional activities by combining the dynamic hip joint segment contact force calculated from the three-dimensional (3D) motion analysis system with the 3D reconstruction of orientation of the acetabular component and each patient’s specific hip joint centre, based on CT scans. Results: Edge-loading in the hips with pseudotumours occurred with a four-fold increase in duration and magnitude of force compared with the hips without pseudotumours (p = 0.02). Conclusions: The study provides the first in vivo evidence to support that edge-loading is an important mechanism that leads to localised excessive wear (edge-wear), with subsequent elevation of metal ion levels in MoMHRA patients with pseudotumours.en_US
dc.language.isoen_USen_US
dc.publisherBritish Editorial Society of Bone and Joint Surgeryen_US
dc.relation.isversionofdoi:10.1302/2046-3758.14.2000019en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626206/pdf/en_US
dash.licenseLAA
dc.subjectPseudotumoursen_US
dc.subjectEdge-Loadingen_US
dc.subjectIn Vivo Evaluationen_US
dc.subjectMetal-on-Metalen_US
dc.subjectHip Resurfacingen_US
dc.subjectMetal Ionsen_US
dc.subjectEdge-loadingen_US
dc.subjectIn vivo evaluationen_US
dc.subjectMetal-on-metalen_US
dc.subjectHip resurfacingen_US
dc.subjectMetal ionsen_US
dc.titleIn vivo evaluation of edge-loading in metal-on-metal hip resurfacing patients with pseudotumoursen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBone & Joint Researchen_US
dash.depositing.authorKwon, Young-Min
dc.date.available2013-10-18T13:58:43Z
dc.identifier.doi10.1302/2046-3758.14.2000019*
dash.contributor.affiliatedKwon, Young-Min


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