Directed differentiation of mouse embryonic stem cells into neocortical output neurons

Sadegh, Cameron

Citation

Sadegh, Cameron. 2013. Directed differentiation of mouse embryonic stem cells into neocortical output neurons. Doctoral dissertation, Harvard University.

Abstract

During development of the neocortex, many diverse projection neuron subtypes are generated under regulation of cell-extrinsic and cell-intrinsic controls. One broad projection neuron class, corticofugal projection neurons (CFuPN), is the primary output neuron population of the neocortex. CFuPN axons innervate sub-cortical targets including thalamus, striatum, brainstem, and spinal cord.

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