Control of Visually Guided Behavior by Distinct Populations of Spinal Projection Neurons

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Control of Visually Guided Behavior by Distinct Populations of Spinal Projection Neurons

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Title: Control of Visually Guided Behavior by Distinct Populations of Spinal Projection Neurons
Author: Orger, Michael B; Kampff, Adam R; Severi, Kristen E; Bollmann, Johann H; Engert, Florian

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Citation: Orger, Michael B., Adam R. Kampff, Kristen E. Severi, Johann H. Bollmann, and Florian Engert. 2008. Control of visually guided behavior by distinct populations of spinal projection neurons. Nature Neuroscience 11(3): 327-333.
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Abstract: A basic question in the field of motor control is how different actions are represented by activity in spinal projection neurons. We used a new behavioral assay to identify visual stimuli that specifically drive basic motor patterns in zebrafish. These stimuli evoked consistent patterns of neural activity in the neurons projecting to the spinal cord, which we could map throughout the entire population using in vivo two-photon calcium imaging. We found that stimuli that drive distinct behaviors activated distinct subsets of projection neurons, consisting, in some cases, of just a few cells. This stands in contrast to the distributed activation seen for more complex behaviors. Furthermore, targeted cell by cell ablations of the neurons associated with evoked turns abolished the corresponding behavioral response. This description of the functional organization of the zebrafish motor system provides a framework for identifying the complete circuit underlying a vertebrate behavior.
Published Version: doi:10.1038/nn2048
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11204671
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