Spatial Constraints Dictate Glial Territories at Murine Neuromuscular Junctions

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Spatial Constraints Dictate Glial Territories at Murine Neuromuscular Junctions

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Title: Spatial Constraints Dictate Glial Territories at Murine Neuromuscular Junctions
Author: Brill, Monika S.; Thompson, Wesley; Zuo, Yi; Misgeld, Thomas; Lichtman, Jeff

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Citation: Brill, Monika S., Jeff W. Lichtman, Wesley Thompson, Yi Zuo, and Thomas Misgeld. 2011. Spatial constraints dictate glial territories at murine neuromuscular junctions. The Journal of Cell Biology 195(2): 293-305.
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Abstract: Schwann cells (SCs), the glial cells of the peripheral nervous system, cover synaptic terminals, allowing them to monitor and modulate neurotransmission. Disruption of glial coverage leads to axon degeneration and synapse loss. The cellular mechanisms that establish and maintain this coverage remain largely unknown. To address this, we labeled single SCs and performed time-lapse imaging experiments. Adult terminal SCs are arranged in static tile patterns, whereas young SCs dynamically intermingle. The mechanism of developmental glial segregation appears to be spatial competition, in which glial–glial and axonal–glial contacts constrain the territory of single SCs, as shown by four types of experiments: (1) laser ablation of single SCs, which led to immediate territory expansion of neighboring SCs; (2) axon removal by transection, resulting in adult SCs intermingling dynamically; (3) axotomy in mutant mice with blocked axon fragmentation in which intermingling was delayed; and (4) activity blockade, which had no immediate effects. In summary, we conclude that glial cells partition synapses by competing for perisynaptic space.
Published Version: doi:10.1083/jcb.201108005
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198169/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11210599
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