Sequencing by Hybridization of Long Targets

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Sequencing by Hybridization of Long Targets

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Title: Sequencing by Hybridization of Long Targets
Author: Qin, Yu; Schneider, Tobias M; Brenner, Michael P.

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Citation: Qin, Yu, Tobias M. Schneider, and Michael P. Brenner. 2012. Sequencing by hybridization of long targets. PLoS ONE 7(5): e35819.
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Abstract: Sequencing by Hybridization (SBH) reconstructs an n-long target DNA sequence from its biochemically determined \(l\)-long subsequences. In the standard approach, the length of a uniformly random sequence that can be unambiguously reconstructed is limited to \(n=O(2^{l})\) due to repetitive subsequences causing reconstruction degeneracies. We present a modified sequencing method that overcomes this limitation without the need for different types of biochemical assays and is robust to error.
Published Version: doi:10.1371/journal.pone.0035819
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344849/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11210605
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