The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment

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The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment

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Title: The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment
Author: Grimes, Catherine Leimkuhler; Ariyananda, Lushanti De Zoysa; Melnyk, James E.; O'Shea, Erin K

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Citation: Grimes, Catherine Leimkuhler, Lushanti De Zoysa Ariyananda, James E. Melnyk, and Erin K. O’Shea. 2012. The innate immune protein nod2 binds directly to mdp, a bacterial cell wall fragment. Journal of the American Chemical Society 134(33): 13535-13537.
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Abstract: Mammalian Nod2 is an intracellular protein that is implicated in the innate immune response to the bacterial cell wall and is associated with the development of Crohn’s disease, Blau syndrome, and gastrointestinal cancers. Nod2 is required for an immune response to muramyl dipeptide (MDP), an immunostimulatory fragment of bacterial cell wall, but it is not known whether MDP binds directly to Nod2. We report the expression and purification of human Nod2 from insect cells. Using novel MDP self-assembled monolayers (SAMs), we provide the first biochemical evidence for a direct, high-affinity interaction between Nod2 and MDP.
Published Version: doi:10.1021/ja303883c
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424850/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11210616
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