The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring

DSpace/Manakin Repository

The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring

Citable link to this page

 

 
Title: The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring
Author: Gaudet, Suzanne; Langlois, Marie-Josée; Lue, Robert Arnold; Rivard, Nathalie; Viel, Alain

Note: Order does not necessarily reflect citation order of authors.

Citation: Gaudet, Suzanne, Marie-Josée Langlois, Robert A Lue, Nathalie Rivard, and Alain Viel. 2011. The mek2-binding tumor suppressor hdlg is recruited by e-cadherin to the midbody ring. BMC Cell Biology 12: 55.
Full Text & Related Files:
Abstract: Background: The human homologue of the Drosophila Discs-large tumor suppressor protein, hDlg, is a multi-domain cytoplasmic protein that localizes to the membrane at intercellular junction sites. At both synaptic junctions and epithelia cell-cell junctions, hDlg is known to recruit several signaling proteins into macromolecular complexes. hDlg is also found at the midbody, a small microtubule-rich structure bridging the two daughter cells during cytokinesis, but its function at this site is not clear. Results: Here we describe the interaction of hDlg with the activated form of MEK2 of the canonical RAF/MEK/ERK pathway, a protein that is found at the midbody during cytokinesis. We show that both proteins localize to a sub-structure of the midbody, the midbody ring, and that the interaction between the PDZ domains of hDlg and the C-terminal portion of MEK2 is dependent on the phosphorylation of MEK2. Finally, we found that E-cadherin also localizes to the midbody and that its expression is required for the isoform-specific recruitment of hDlg, but not activated MEK2, to that structure. Conclusion: Our results suggest that like at other cell-cell junction sites, hDlg is part of a macromolecular complex of structural and signaling proteins at the midbody.
Published Version: doi:10.1186/1471-2121-12-55
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268111/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11210623
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters