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dc.contributor.authorCowling, Benjamin J
dc.contributor.authorFang, Vicky J
dc.contributor.authorHagy, Angela
dc.contributor.authorReshef, David
dc.contributor.authorBiedrzycki, Paul
dc.contributor.authorGoldstein, Edward
dc.contributor.authorO'Hagan, Justin John
dc.contributor.authorDanon, Leon
dc.contributor.authorMiller, Joel C.
dc.contributor.authorRobins, James Matthew
dc.contributor.authorLipsitch, Marc
dc.date.accessioned2013-10-25T11:40:51Z
dc.date.issued2010
dc.identifier.citationGoldstein, Edward, Benjamin J. Cowling, Justin J. O'Hagan, Leon Danon, Vicky J. Fang, Angela Hagy, Joel C. Miller, et al. 2010. Oseltamivir for treatment and prevention of pandemic influenza A/H1N1 virus infection in households, Milwaukee, 2009. BMC Infectious Diseases 10: 211.en_US
dc.identifier.issn1471-2334en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11213312
dc.description.abstractBackground: During an influenza pandemic, a substantial proportion of transmission is thought to occur in households. We used data on influenza progression in individuals and their contacts collected by the City of Milwaukee Health Department (MHD) to study the transmission of pandemic influenza A/H1N1 virus in 362 households in Milwaukee, WI, and the effects of oseltamivir treatment and chemoprophylaxis. Methods: 135 households had chronological information on symptoms and oseltamivir usage for all household members. The effect of oseltamivir treatment and other factors on the household secondary attack rate was estimated using univariate and multivariate logistic regression with households as the unit of analysis. The effect of oseltamivir treatment and other factors on the individual secondary attack rate was estimated using univariate and multivariate logistic regression with individual household contacts as the unit of analysis, and a generalized estimating equations approach was used to fit the model to allow for clustering within households. Results: Oseltamivir index treatment on onset day or the following day (early treatment) was associated with a 42% reduction (OR: 0.58, 95% CI: 0.19, 1.73) in the odds of one or more secondary infections in a household and a 50% reduction (OR: 0.5, 95% CI: 0.17, 1.46) in the odds of a secondary infection in individual contacts. The confidence bounds are wide due to a small sample of households with early oseltamivir index usage - in 29 such households, 5 had a secondary attack. Younger household contacts were at higher risk of infection (OR: 2.79, 95% CI: 1.50-5.20). Conclusions: Early oseltamivir treatment may be beneficial in preventing H1N1pdm influenza transmission; this may have relevance to future control measures for influenza pandemics. Larger randomized trials are needed to confirm this finding statistically.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1471-2334-10-211en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919545/pdf/en_US
dash.licenseLAA
dc.titleOseltamivir for treatment and prevention of pandemic influenza A/H1N1 virus infection in households, Milwaukee, 2009en_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Infectious Diseasesen_US
dash.depositing.authorLipsitch, Marc
dc.date.available2013-10-25T11:40:51Z
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherFAS^FCOL^Freshman Dean's Ofc - Other Academicen_US
dash.affiliation.otherSPH^Student Stipendsen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dc.identifier.doi10.1186/1471-2334-10-211*
workflow.legacycommentsFLAG8 HSPHen_US
dash.authorsorderedfalse
dash.contributor.affiliatedRobins, James
dash.contributor.affiliatedO'Hagan, Justin
dash.contributor.affiliatedMiller, Joel C.
dash.contributor.affiliatedDanon, Leon
dash.contributor.affiliatedGoldstein, Edward
dash.contributor.affiliatedLipsitch, Marc


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