Genomic Hotspots for Adaptation: The Population Genetics of Müllerian Mimicry in the Heliconius melpomene Clade

DSpace/Manakin Repository

Genomic Hotspots for Adaptation: The Population Genetics of Müllerian Mimicry in the Heliconius melpomene Clade

Show simple item record

dc.contributor.author Baxter, Simon W.
dc.contributor.author Nadeau, Nicola J.
dc.contributor.author Maroja, Luana S.
dc.contributor.author Wilkinson, Paul
dc.contributor.author Counterman, Brian A.
dc.contributor.author Dawson, Anna
dc.contributor.author Beltran, Margarita
dc.contributor.author Perez-Espona, Silvia
dc.contributor.author Ferguson, Laura
dc.contributor.author Davidson, Claire
dc.contributor.author Glithero, Rebecca
dc.contributor.author Mallet, James
dc.contributor.author Joron, Mathieu
dc.contributor.author ffrench-Constant, Richard H.
dc.contributor.author Jiggins, Chris D.
dc.contributor.author Chamberlain, Nicola L
dc.contributor.author Clark, Richard
dc.contributor.author McMillan, W. Owen
dc.contributor.author Kronforst, Marcus
dc.date.accessioned 2013-10-25T11:43:16Z
dc.date.issued 2010
dc.identifier.citation Baxter, Simon W., Nicola J. Nadeau, Luana S. Maroja, Paul Wilkinson, Brian A. Counterman, Anna Dawson, Margarita Beltran, et al. 2010. Genomic Hotspots for Adaptation: The Population Genetics of Müllerian Mimicry in the Heliconius melpomene Clade. PLoS Genetics 6(2): e1000794. en_US
dc.identifier.issn 1553-7390 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:11213313
dc.description.abstract Wing patterning in Heliconius butterflies is a longstanding example of both Müllerian mimicry and phenotypic radiation under strong natural selection. The loci controlling such patterns are “hotspots” for adaptive evolution with great allelic diversity across different species in the genus. We characterise nucleotide variation, genotype-by-phenotype associations, linkage disequilibrium, and candidate gene expression at two loci and across multiple hybrid zones in Heliconius melpomene and relatives. Alleles at HmB control the presence or absence of the red forewing band, while alleles at HmYb control the yellow hindwing bar. Across HmYb two regions, separated by ∼100 kb, show significant genotype-by-phenotype associations that are replicated across independent hybrid zones. In contrast, at HmB a single peak of association indicates the likely position of functional sites at three genes, encoding a kinesin, a G-protein coupled receptor, and an mRNA splicing factor. At both HmYb and HmB there is evidence for enhanced linkage disequilibrium (LD) between associated sites separated by up to 14 kb, suggesting that multiple sites are under selection. However, there was no evidence for reduced variation or deviations from neutrality that might indicate a recent selective sweep, consistent with these alleles being relatively old. Of the three genes showing an association with the HmB locus, the kinesin shows differences in wing disc expression between races that are replicated in the co-mimic, Heliconius erato, providing striking evidence for parallel changes in gene expression between Müllerian co-mimics. Wing patterning loci in Heliconius melpomene therefore show a haplotype structure maintained by selection, but no evidence for a recent selective sweep. The complex genetic pattern contrasts with the simple genetic basis of many adaptive traits studied previously, but may provide a better model for most adaptation in natural populations that has arisen over millions rather than tens of years. en_US
dc.description.sponsorship Other Research Unit en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pgen.1000794 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816687/pdf/ en_US
dash.license LAA
dc.subject evolutionary biology en_US
dc.subject animal genetics en_US
dc.subject bioinformatics en_US
dc.subject developmental evolution en_US
dc.subject evolutionary and comparative genetics en_US
dc.subject genomics en_US
dc.subject pattern formation en_US
dc.title Genomic Hotspots for Adaptation: The Population Genetics of Müllerian Mimicry in the Heliconius melpomene Clade en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS Genetics en_US
dash.depositing.author Kronforst, Marcus
dc.date.available 2013-10-25T11:43:16Z
dash.affiliation.other FAS^FCOR^FAS Center for Systems Biology - Oth en_US

Files in this item

Files Size Format View
2816687.pdf 1002.Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters