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dc.contributor.authorBaxter, Simon W.
dc.contributor.authorNadeau, Nicola J.
dc.contributor.authorMaroja, Luana S.
dc.contributor.authorWilkinson, Paul
dc.contributor.authorCounterman, Brian A.
dc.contributor.authorDawson, Anna
dc.contributor.authorBeltran, Margarita
dc.contributor.authorPerez-Espona, Silvia
dc.contributor.authorFerguson, Laura
dc.contributor.authorDavidson, Claire
dc.contributor.authorGlithero, Rebecca
dc.contributor.authorMallet, James
dc.contributor.authorJoron, Mathieu
dc.contributor.authorffrench-Constant, Richard H.
dc.contributor.authorJiggins, Chris D.
dc.contributor.authorChamberlain, Nicola L
dc.contributor.authorClark, Richard
dc.contributor.authorMcMillan, W. Owen
dc.contributor.authorKronforst, Marcus
dc.date.accessioned2013-10-25T11:43:16Z
dc.date.issued2010
dc.identifier.citationBaxter, Simon W., Nicola J. Nadeau, Luana S. Maroja, Paul Wilkinson, Brian A. Counterman, Anna Dawson, Margarita Beltran, et al. 2010. Genomic Hotspots for Adaptation: The Population Genetics of Müllerian Mimicry in the Heliconius melpomene Clade. PLoS Genetics 6(2): e1000794.en_US
dc.identifier.issn1553-7390en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11213313
dc.description.abstractWing patterning in Heliconius butterflies is a longstanding example of both Müllerian mimicry and phenotypic radiation under strong natural selection. The loci controlling such patterns are “hotspots” for adaptive evolution with great allelic diversity across different species in the genus. We characterise nucleotide variation, genotype-by-phenotype associations, linkage disequilibrium, and candidate gene expression at two loci and across multiple hybrid zones in Heliconius melpomene and relatives. Alleles at HmB control the presence or absence of the red forewing band, while alleles at HmYb control the yellow hindwing bar. Across HmYb two regions, separated by ∼100 kb, show significant genotype-by-phenotype associations that are replicated across independent hybrid zones. In contrast, at HmB a single peak of association indicates the likely position of functional sites at three genes, encoding a kinesin, a G-protein coupled receptor, and an mRNA splicing factor. At both HmYb and HmB there is evidence for enhanced linkage disequilibrium (LD) between associated sites separated by up to 14 kb, suggesting that multiple sites are under selection. However, there was no evidence for reduced variation or deviations from neutrality that might indicate a recent selective sweep, consistent with these alleles being relatively old. Of the three genes showing an association with the HmB locus, the kinesin shows differences in wing disc expression between races that are replicated in the co-mimic, Heliconius erato, providing striking evidence for parallel changes in gene expression between Müllerian co-mimics. Wing patterning loci in Heliconius melpomene therefore show a haplotype structure maintained by selection, but no evidence for a recent selective sweep. The complex genetic pattern contrasts with the simple genetic basis of many adaptive traits studied previously, but may provide a better model for most adaptation in natural populations that has arisen over millions rather than tens of years.en_US
dc.description.sponsorshipOther Research Uniten_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pgen.1000794en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816687/pdf/en_US
dash.licenseLAA
dc.subjectevolutionary biologyen_US
dc.subjectanimal geneticsen_US
dc.subjectbioinformaticsen_US
dc.subjectdevelopmental evolutionen_US
dc.subjectevolutionary and comparative geneticsen_US
dc.subjectgenomicsen_US
dc.subjectpattern formationen_US
dc.titleGenomic Hotspots for Adaptation: The Population Genetics of Müllerian Mimicry in the Heliconius melpomene Cladeen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Geneticsen_US
dash.depositing.authorKronforst, Marcus
dc.date.available2013-10-25T11:43:16Z
dash.affiliation.otherFAS^FCOR^FAS Center for Systems Biology - Othen_US
dc.identifier.doi10.1371/journal.pgen.1000794*
dash.authorsorderedfalse
dash.contributor.affiliatedChamberlain, Nicola
dash.contributor.affiliatedKronforst, Marcus


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