Cancer proliferation and therapy: the Warburg effect and quantum metabolism

DSpace/Manakin Repository

Cancer proliferation and therapy: the Warburg effect and quantum metabolism

Citable link to this page

 

 
Title: Cancer proliferation and therapy: the Warburg effect and quantum metabolism
Author: Coy, Johannes F; Tuszynski, Jack A; Demetrius, Lloyd A.

Note: Order does not necessarily reflect citation order of authors.

Citation: Demetrius, Lloyd A., Johannes F. Coy, and Jack A. Tuszynski. 2010. Cancer proliferation and therapy: the Warburg effect and quantum metabolism. Theoretical Biology & Medical Modelling 7: 2.
Full Text & Related Files:
Abstract: Background: Most cancer cells, in contrast to normal differentiated cells, rely on aerobic glycolysis instead of oxidative phosphorylation to generate metabolic energy, a phenomenon called the Warburg effect. Model: Quantum metabolism is an analytic theory of metabolic regulation which exploits the methodology of quantum mechanics to derive allometric rules relating cellular metabolic rate and cell size. This theory explains differences in the metabolic rates of cells utilizing OxPhos and cells utilizing glycolysis. This article appeals to an analytic relation between metabolic rate and evolutionary entropy - a demographic measure of Darwinian fitness - to: (a) provide an evolutionary rationale for the Warburg effect, and (b) propose methods based on entropic principles of natural selection for regulating the incidence of OxPhos and glycolysis in cancer cells. Conclusion: The regulatory interventions proposed on the basis of quantum metabolism have applications in therapeutic strategies to combat cancer. These procedures, based on metabolic regulation, are non-invasive, and complement the standard therapeutic methods involving radiation and chemotherapy
Published Version: doi:10.1186/1742-4682-7-2
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819045/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11213330
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters