Foxp3 Interacts With c-Rel to Mediate NF-\(\kappa\)B Repression

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Foxp3 Interacts With c-Rel to Mediate NF-\(\kappa\)B Repression

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Title: Foxp3 Interacts With c-Rel to Mediate NF-\(\kappa\)B Repression
Author: Loizou, Louiza; Betz, Alexander G.; Andersen, Kristian G

Note: Order does not necessarily reflect citation order of authors.

Citation: Loizou, Louiza, Kristian G. Andersen, and Alexander G. Betz. 2011. Foxp3 interacts with c-Rel to mediate NF-\(\kappa\)B repression. PLoS ONE 6(4).
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Abstract: Expression of the lineage-specific DNA-binding factor Foxp3 controls the development and function of naturally occurring regulatory T cells. Foxp3 has been shown to interact with a multitude of transcriptional regulators including NFAT, NF-\(\kappa\)B (p65), Runx1 and ROR\(\lambda\)t, as well as the histone modification enzymes TIP60, HDAC7 and HDAC9. The sum of these interactions is believed to cause the change in the transcriptional program of regulatory T cells. Here we show that Foxp3 directly or as part of a multimeric complex engages with the NF-\(\kappa\)B component c-Rel. We demonstrate that the N-terminal region of Foxp3 is required for the binding of c-Rel, but not NFAT. Conversely, deletion of the forkhead domain causes a loss of interaction with NFAT, but not c-Rel. Our findings are of particular interest, as c-Rel is crucial for the induction of Foxp3 in regulatory T cells during thymic development, but has to be repressed in mature regulatory T cells to maintain their suppressive phenotype.
Published Version: doi://10.1371/journal.pone.0018670
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072406/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11213364
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