Intravenous tPA Therapy Does Not Worsen Acute Intracerebral Hemorrhage in Mice

DSpace/Manakin Repository

Intravenous tPA Therapy Does Not Worsen Acute Intracerebral Hemorrhage in Mice

Citable link to this page


Title: Intravenous tPA Therapy Does Not Worsen Acute Intracerebral Hemorrhage in Mice
Author: Foerch, Christian; Rosidi, Nathanael L.; Schlunk, Frieder; Lauer, Arne; Cianchetti, Flor A.; Mandeville, Emiri T; Arai, Ken; Yigitkanli, Kazim; Fan, Xiang; Wang, Xiaoying; van Leyen, Klaus J.; Steinmetz, Helmuth; Schaffer, Chris B.; Lo, Eng H.

Note: Order does not necessarily reflect citation order of authors.

Citation: Foerch, Christian, Nathanael L. Rosidi, Frieder Schlunk, Arne Lauer, Flor A. Cianchetti, Emiri Mandeville, Ken Arai, et al. 2013. Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PLoS ONE 8(2): e54203.
Full Text & Related Files:
Abstract: Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH). Surprisingly, however, the assumption that tPA will worsen ICH has never been biologically tested. Here, we assessed the effects of tPA in two models of ICH. In a mouse model of collagenase-induced ICH, hemorrhage volumes and neurological deficits after 24 hrs were similar in saline controls and tPA-treated mice, whereas heparin-treated mice had 3-fold larger hematomas. In a model of laser-induced vessel rupture, tPA also did not worsen hemorrhage volumes, while heparin did. tPA is known to worsen neurovascular injury by amplifying matrix metalloproteinases during cerebral ischemia. In contrast, tPA did not upregulate matrix metalloproteinases in our mouse ICH models. In summary, our experimental data do not support the assumption that intravenous tPA has a deleterious effect in acute ICH. However, due to potential species differences and the inability of models to fully capture the dynamics of human ICH, caution is warranted when considering the implications of these findings for human therapy.
Published Version: doi:10.1371/journal.pone.0054203
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search