Anisotropic light scattering of individual sickle red blood cells

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Anisotropic light scattering of individual sickle red blood cells

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Title: Anisotropic light scattering of individual sickle red blood cells
Author: Kim, Youngchan; Higgins, John Matthew; Dasari, Ramachandra R.; Suresh, Subra; Park, YongKeun

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Citation: Kim, Youngchan, John M. Higgins, Ramachandra R. Dasari, Subra Suresh, and YongKeun Park. 2012. Anisotropic light scattering of individual sickle red blood cells. Journal of Biomedical Optics 17(4): 040501.
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Abstract: Abstract. We present the anisotropic light scattering of individual red blood cells (RBCs) from a patient with sickle cell disease (SCD). To measure light scattering spectra along two independent axes of elongated-shaped sickle RBCs with arbitrary orientation, we introduce the anisotropic Fourier transform light scattering (aFTLS) technique and measured both the static and dynamic anisotropic light scattering. We observed strong anisotropy in light scattering patterns of elongated-shaped sickle RBCs along its major axes using static aFTLS. Dynamic aFTLS analysis reveals the significantly altered biophysical properties in individual sickle RBCs. These results provide evidence that effective viscosity and elasticity of sickle RBCs are significantly different from those of the healthy RBCs.
Published Version: doi:10.1117/1.JBO.17.4.040501
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602817/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11266835
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