TRP Channels Entering the Structural Era

DSpace/Manakin Repository

TRP Channels Entering the Structural Era

Citable link to this page


Title: TRP Channels Entering the Structural Era
Author: Gaudet, Rachelle
Citation: Gaudet, Rachelle. 2008. TRP channels entering the structural era. The Journal of Physiology 586(15): 3565-3575.
Full Text & Related Files:
Abstract: Transient receptor potential (TRP) channels are important in many neuronal and non-neuronal physiological processes. The past 2 years have seen much progress in the use of structural biology techniques to elucidate molecular mechanisms of TRP channel gating and regulation. Two approaches have proven fruitful: (i) a divide-and-conquer strategy has provided high-resolution structural details of TRP channel fragments although it fails to explain how these fragments are integrated in the full channel; and (ii) electron microscopy of entire TRP channels has yielded low-resolution images that provide a basis for testable models of TRP channel architecture. The results of each approach, summarized in this review, provide a preview of what the future holds in TRP channel structural biology.
Published Version: doi:10.1113/jphysiol.2008.155812
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search