Show simple item record

dc.contributor.authorChoi, Noah Chan H
dc.contributor.authorChun, Tristen T.
dc.contributor.authorNiemierko, Andrzej
dc.contributor.authorAncukiewicz, Marek
dc.contributor.authorFidias, Panos M.
dc.contributor.authorKradin, Richard Lawrence
dc.contributor.authorMathisen, Douglas James
dc.contributor.authorLynch, Thomas J.
dc.contributor.authorFischman, Alan J.
dc.date.accessioned2013-12-06T18:10:14Z
dc.date.issued2013
dc.identifier.citationChoi, Noah C., Tristen T. Chun, Andrzej Niemierko, Marek Ancukiewicz, Panos M. Fidias, Richard L. Kradin, Douglas J. Mathisen, Thomas J. Lynch, and Alan J. Fischman. 2013. Potential of 18f-fdg pet toward personalized radiotherapy or chemoradiotherapy in lung cancer. European Journal of Nuclear Medicine and Molecular Imaging 40(6): 832-841.en_US
dc.identifier.issn1619-7070en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11357486
dc.description.abstractPurpose We investigated the metabolic response of lung cancer to radiotherapy or chemoradiotherapy by 18F-FDG PET and its utility in guiding timely supplementary therapy. Methods: Glucose metabolic rate (MRglc) was measured in primary lung cancers during the 3 weeks before, and 10–12 days (S2), 3 months (S3), 6 months (S4), and 12 months (S5) after radiotherapy or chemoradiotherapy. The association between the lowest residual MRglc representing the maximum metabolic response (MRglc-MMR) and tumor control probability (TCP) at 12 months was modeled using logistic regression. Results: We accrued 106 patients, of whom 61 completed the serial 18F-FDG PET scans. The median values of MRglc at S2, S3 and S4 determined using a simplified kinetic method (SKM) were, respectively, 0.05, 0.06 and 0.07 μmol/min/g for tumors with local control and 0.12, 0.16 and 0.19 μmol/min/g for tumors with local failure, and the maximum standard uptake values (SUVmax) were 1.16, 1.33 and 1.45 for tumors with local control and 2.74, 2.74 and 4.07 for tumors with local failure (p < 0.0001). MRglc-MMR was realized at S2 (MRglc-S2) and the values corresponding to TCP 95 %, 90 % and 50 % were 0.036, 0.050 and 0.134 μmol/min/g using the SKM and 0.70, 0.91 and 1.95 using SUVmax, respectively. Probability cut-off values were generated for a given level of MRglc-S2 based on its predicted TCP, sensitivity and specificity, and MRglc ≤0.071 μmol/min/g and SUVmax ≤1.45 were determined as the optimum cut-off values for predicted TCP 80 %, sensitivity 100 % and specificity 63 %. Conclusion: The cut-off values (MRglc ≤0.071 μmol/min/g using the SKM and SUVmax ≤1.45) need to be tested for their utility in identifying patients with a high risk of residual cancer after standard dose radiotherapy or chemoradiotherapy and in guiding a timely supplementary dose of radiation or other means of salvage therapy. Electronic supplementary material The online version of this article (doi:10.1007/s00259-013-2348-4) contains supplementary material, which is available to authorized users.en_US
dc.language.isoen_USen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofdoi:10.1007/s00259-013-2348-4en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644202/pdf/en_US
dash.licenseLAA
dc.subjectF-FDG PETen_US
dc.subjectPersonalized radiotherapyen_US
dc.subjectIndividualized therapyen_US
dc.subjectLung canceren_US
dc.subjectChemoradiotherapyen_US
dc.titlePotential of 18F-FDG PET toward personalized radiotherapy or chemoradiotherapy in lung canceren_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEuropean Journal of Nuclear Medicine and Molecular Imagingen_US
dash.depositing.authorChoi, Noah Chan H
dc.date.available2013-12-06T18:10:14Z
dc.identifier.doi10.1007/s00259-013-2348-4*
dash.contributor.affiliatedMathisen, Douglas
dash.contributor.affiliatedKradin, Richard
dash.contributor.affiliatedChoi, Noah
dash.contributor.affiliatedAncukiewicz, Marek
dash.contributor.affiliatedNiemierko, Andrzej


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record