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dc.contributor.authorDadvand, Payam
dc.contributor.authorParker, Jennifer
dc.contributor.authorBell, Michelle L.
dc.contributor.authorBonzini, Matteo
dc.contributor.authorBrauer, Michael
dc.contributor.authorDarrow, Lyndsey A.
dc.contributor.authorGehring, Ulrike
dc.contributor.authorGlinianaia, Svetlana V.
dc.contributor.authorGouveia, Nelson
dc.contributor.authorHa, Eun-hee
dc.contributor.authorLeem, Jong Han
dc.contributor.authorvan den Hooven, Edith H.
dc.contributor.authorJalaludin, Bin
dc.contributor.authorJesdale, Bill M.
dc.contributor.authorLepeule, Johanna
dc.contributor.authorMorello-Frosch, Rachel
dc.contributor.authorMorgan, Geoffrey G.
dc.contributor.authorPesatori, Angela Cecilia
dc.contributor.authorPierik, Frank H.
dc.contributor.authorPless-Mulloli, Tanja
dc.contributor.authorRich, David Q.
dc.contributor.authorSathyanarayana, Sheela
dc.contributor.authorSeo, Juhee
dc.contributor.authorSlama, Rémy
dc.contributor.authorStrickland, Matthew
dc.contributor.authorTamburic, Lillian
dc.contributor.authorWartenberg, Daniel
dc.contributor.authorNieuwenhuijsen, Mark J.
dc.contributor.authorWoodruff, Tracey J.
dc.date.accessioned2013-12-11T17:38:52Z
dc.date.issued2013
dc.identifier.citationDadvand, Payam, Jennifer Parker, Michelle L. Bell, Matteo Bonzini, Michael Brauer, Lyndsey A. Darrow, Ulrike Gehring, et al. 2013. Maternal exposure to particulate air pollution and term birth weight: a multi-country evaluation of effect and heterogeneity. Environmental Health Perspectives 121(3): 267-373.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11365872
dc.description.abstractBackground: A growing body of evidence has associated maternal exposure to air pollution with adverse effects on fetal growth; however, the existing literature is inconsistent. Objectives: We aimed to quantify the association between maternal exposure to particulate air pollution and term birth weight and low birth weight (LBW) across 14 centers from 9 countries, and to explore the influence of site characteristics and exposure assessment methods on between-center heterogeneity in this association. Methods: Using a common analytical protocol, International Collaboration on Air Pollution and Pregnancy Outcomes (ICAPPO) centers generated effect estimates for term LBW and continuous birth weight associated with PM10 and PM2.5 (particulate matter ≤ 10 and 2.5 µm). We used meta-analysis to combine the estimates of effect across centers (~ 3 million births) and used meta-regression to evaluate the influence of center characteristics and exposure assessment methods on between-center heterogeneity in reported effect estimates. Results: In random-effects meta-analyses, term LBW was positively associated with a 10-μg/m3 increase in PM10 [odds ratio (OR) = 1.03; 95% CI: 1.01, 1.05] and PM2.5 (OR = 1.10; 95% CI: 1.03, 1.18) exposure during the entire pregnancy, adjusted for maternal socioeconomic status. A 10-μg/m3 increase in PM10 exposure was also negatively associated with term birth weight as a continuous outcome in the fully adjusted random-effects meta-analyses (–8.9 g; 95% CI: –13.2, –4.6 g). Meta-regressions revealed that centers with higher median PM2.5 levels and PM2.5:PM10 ratios, and centers that used a temporal exposure assessment (compared with spatiotemporal), tended to report stronger associations. Conclusion: Maternal exposure to particulate pollution was associated with LBW at term across study populations. We detected three site characteristics and aspects of exposure assessment methodology that appeared to contribute to the variation in associations reported by centers.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.1205575en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621183/pdf/en_US
dash.licenseLAA
dc.subjectair pollutionen_US
dc.subjectfetal growthen_US
dc.subjectheterogeneityen_US
dc.subjectICAPPOen_US
dc.subjectlow birth weighten_US
dc.subjectmeta-analysisen_US
dc.subjectmeta-regressionen_US
dc.subjectmulti-center studyen_US
dc.subjectparticulate matteren_US
dc.subjectpregnancyen_US
dc.titleMaternal Exposure to Particulate Air Pollution and Term Birth Weight: A Multi-Country Evaluation of Effect and Heterogeneityen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorLepeule, Johanna
dc.date.available2013-12-11T17:38:52Z
dc.identifier.doi10.1289/ehp.1205575*
dash.authorsorderedfalse
dash.contributor.affiliatedLepeule, Johanna


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