Metagenomic microbial community profiling using unique clade-specific marker genes

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Metagenomic microbial community profiling using unique clade-specific marker genes

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Title: Metagenomic microbial community profiling using unique clade-specific marker genes
Author: Segata, Nicola; Waldron, Levi D.; Ballarini, Annalisa; Narasimhan, Vagheesh; Jousson, Olivier; Huttenhower, Curtis

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Citation: Segata, Nicola, Levi Waldron, Annalisa Ballarini, Vagheesh Narasimhan, Olivier Jousson, and Curtis Huttenhower. 2012. Metagenomic microbial community profiling using unique clade-specific marker genes. Nature methods 9(8): 811-814.
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Abstract: Metagenomic shotgun sequencing data can identify microbes populating a microbial community and their proportions, but existing taxonomic profiling methods are inefficient for increasingly large datasets. We present an approach that uses clade-specific marker genes to unambiguously assign reads to microbial clades more accurately and >50× faster than current approaches. We validated MetaPhlAn on terabases of short reads and provide the largest metagenomic profiling to date of the human gut
Published Version: doi:10.1038/nmeth.2066
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443552/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11369874
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