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dc.contributor.authorAgus, David B.
dc.contributor.authorAlexander, Jenolyn F.
dc.contributor.authorArap, Wadih
dc.contributor.authorAshili, Shashanka
dc.contributor.authorAslan, Joseph E.
dc.contributor.authorAustin, Robert H.
dc.contributor.authorBackman, Vadim
dc.contributor.authorBethel, Kelly J.
dc.contributor.authorBonneau, Richard
dc.contributor.authorChen, Wei-Chiang
dc.contributor.authorChen-Tanyolac, Chira
dc.contributor.authorChoi, Nathan C.
dc.contributor.authorCurley, Steven A.
dc.contributor.authorDallas, Matthew
dc.contributor.authorDamania, Dhwanil
dc.contributor.authorDavies, Paul C. W.
dc.contributor.authorDecuzzi, Paolo
dc.contributor.authorDickinson, Laura
dc.contributor.authorEstevez-Salmeron, Luis
dc.contributor.authorEstrella, Veronica
dc.contributor.authorFerrari, Mauro
dc.contributor.authorFischbach, Claudia
dc.contributor.authorFoo, Jasmine
dc.contributor.authorFraley, Stephanie I.
dc.contributor.authorFrantz, Christian
dc.contributor.authorFuhrmann, Alexander
dc.contributor.authorGascard, Philippe
dc.contributor.authorGatenby, Robert A.
dc.contributor.authorGeng, Yue
dc.contributor.authorGerecht, Sharon
dc.contributor.authorGillies, Robert J.
dc.contributor.authorGodin, Biana
dc.contributor.authorGrady, William M.
dc.contributor.authorGreenfield, Alex
dc.contributor.authorHemphill, Courtney
dc.contributor.authorHempstead, Barbara L.
dc.contributor.authorHielscher, Abigail
dc.contributor.authorHillis, W. Daniel
dc.contributor.authorHolland, Eric C.
dc.contributor.authorIbrahim-Hashim, Arig
dc.contributor.authorJacks, Tyler
dc.contributor.authorJohnson, Roger H.
dc.contributor.authorJoo, Ahyoung
dc.contributor.authorKatz, Jonathan E.
dc.contributor.authorKelbauskas, Laimonas
dc.contributor.authorKesselman, Carl
dc.contributor.authorKing, Michael R.
dc.contributor.authorKonstantopoulos, Konstantinos
dc.contributor.authorKraning-Rush, Casey M.
dc.contributor.authorKuhn, Peter
dc.contributor.authorKung, Kevin
dc.contributor.authorKwee, Brian
dc.contributor.authorLakins, Johnathon N.
dc.contributor.authorLambert, Guillaume
dc.contributor.authorLiao, David
dc.contributor.authorLicht, Jonathan D.
dc.contributor.authorLiphardt, Jan T.
dc.contributor.authorLiu, Liyu
dc.contributor.authorLloyd, Mark C.
dc.contributor.authorLyubimova, Anna
dc.contributor.authorMallick, Parag
dc.contributor.authorMarko, John
dc.contributor.authorMcCarty, Owen J. T.
dc.contributor.authorMeldrum, Deirdre R.
dc.contributor.authorMichor, Franziska L.
dc.contributor.authorMumenthaler, Shannon M.
dc.contributor.authorNandakumar, Vivek
dc.contributor.authorO’Halloran, Thomas V.
dc.contributor.authorOh, Steve
dc.contributor.authorPasqualini, Renata
dc.contributor.authorPaszek, Matthew J.
dc.contributor.authorPhilips, Kevin G.
dc.contributor.authorPoultney, Christopher S.
dc.contributor.authorRana, Kuldeepsinh
dc.contributor.authorReinhart-King, Cynthia A.
dc.contributor.authorRos, Robert
dc.contributor.authorSemenza, Gregg L.
dc.contributor.authorSenechal, Patti
dc.contributor.authorShuler, Michael L.
dc.contributor.authorSrinivasan, Srimeenakshi
dc.contributor.authorStaunton, Jack R.
dc.contributor.authorStypula, Yolanda
dc.contributor.authorSubramanian, Hariharan
dc.contributor.authorTlsty, Thea D.
dc.contributor.authorTormoen, Garth W.
dc.contributor.authorTseng, Yiider
dc.contributor.authorvan Oudenaarden, Alexander
dc.contributor.authorVerbridge, Scott S.
dc.contributor.authorWan, Jenny C.
dc.contributor.authorWeaver, Valerie M.
dc.contributor.authorWidom, Jonathan
dc.contributor.authorWill, Christine
dc.contributor.authorWirtz, Denis
dc.contributor.authorWojtkowiak, Jonathan
dc.contributor.authorWu, Pei-Hsun
dc.date.accessioned2013-12-11T20:00:19Z
dc.date.issued2013
dc.identifier.citationAgus, David B., Jenolyn F. Alexander, Wadih Arap, Shashanka Ashili, Joseph E. Aslan, Robert H. Austin, Vadim Backman, et al. 2013. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports 3:1449.en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11370206
dc.description.abstractTo investigate the transition from non-cancerous to metastatic from a physical sciences perspective, the Physical Sciences–Oncology Centers (PS-OC) Network performed molecular and biophysical comparative studies of the non-tumorigenic MCF-10A and metastatic MDA-MB-231 breast epithelial cell lines, commonly used as models of cancer metastasis. Experiments were performed in 20 laboratories from 12 PS-OCs. Each laboratory was supplied with identical aliquots and common reagents and culture protocols. Analyses of these measurements revealed dramatic differences in their mechanics, migration, adhesion, oxygen response, and proteomic profiles. Model-based multi-omics approaches identified key differences between these cells' regulatory networks involved in morphology and survival. These results provide a multifaceted description of cellular parameters of two widely used cell lines and demonstrate the value of the PS-OC Network approach for integration of diverse experimental observations to elucidate the phenotypes associated with cancer metastasis.en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/srep01449en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636513/pdf/en_US
dash.licenseLAA
dc.titleA physical sciences network characterization of non-tumorigenic and metastatic cellsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalScientific Reportsen_US
dash.depositing.authorMichor, Franziska L.
dc.date.available2013-12-11T20:00:19Z
dc.identifier.doi10.1038/srep01449*
dash.authorsorderedfalse
dash.contributor.affiliatedMichor, Franziska


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