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dc.contributor.authorGhoussaini, Maya
dc.contributor.authorFletcher, Olivia
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorTurnbull, Clare
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.authorDicks, Ed
dc.contributor.authorDennis, Joe
dc.contributor.authorWang, Qin
dc.contributor.authorHumphreys, Manjeet K
dc.contributor.authorLuccarini, Craig
dc.contributor.authorBaynes, Caroline
dc.contributor.authorConroy, Don
dc.contributor.authorMaranian, Melanie
dc.contributor.authorAhmed, Shahana
dc.contributor.authorDriver, Kristy
dc.contributor.authorJohnson, Nichola
dc.contributor.authorOrr, Nicholas
dc.contributor.authorSilva, Isabel dos Santos
dc.contributor.authorWaisfisz, Quinten
dc.contributor.authorMeijers-Heijboer, Hanne
dc.contributor.authorUitterlinden, Andre G.
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorHall, Per
dc.contributor.authorCzene, Kamila
dc.contributor.authorIrwanto, Astrid
dc.contributor.authorLiu, Jianjun
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorMeindl, Alfons
dc.contributor.authorSchmutzler, Rita K
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorLichtner, Peter
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorHein, Rebecca
dc.contributor.authorNickels, Stefan
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorTsimiklis, Helen
dc.contributor.authorMakalic, Enes
dc.contributor.authorSchmidt, Daniel
dc.contributor.authorBui, Minh
dc.contributor.authorHopper, John L
dc.contributor.authorApicella, Carmel
dc.contributor.authorPark, Daniel J
dc.contributor.authorSouthey, Melissa
dc.contributor.authorHunter, David J.
dc.contributor.authorChanock, Stephen J
dc.contributor.authorBroeks, Annegien
dc.contributor.authorVerhoef, Senno
dc.contributor.authorHogervorst, Frans BL
dc.contributor.authorFasching, Peter A.
dc.contributor.authorLux, Michael P.
dc.contributor.authorBeckmann, Matthias W.
dc.contributor.authorEkici, Arif B.
dc.contributor.authorSawyer, Elinor
dc.contributor.authorTomlinson, Ian
dc.contributor.authorKerin, Michael
dc.contributor.authorMarme, Frederik
dc.contributor.authorSchneeweiss, Andreas
dc.contributor.authorSohn, Christof
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorGuénel, Pascal
dc.contributor.authorTruong, Thérèse
dc.contributor.authorCordina-Duverger, Emilie
dc.contributor.authorMenegaux, Florence
dc.contributor.authorBojesen, Stig E
dc.contributor.authorNordestgaard, Børge G
dc.contributor.authorNielsen, Sune F
dc.contributor.authorFlyger, Henrik
dc.contributor.authorMilne, Roger L.
dc.contributor.authorAlonso, M. Rosario
dc.contributor.authorGonzález-Neira, Anna
dc.contributor.authorBenítez, Javier
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorBernstein, Leslie
dc.contributor.authorDur, Christina Clarke
dc.contributor.authorBrenner, Hermann
dc.contributor.authorMüller, Heiko
dc.contributor.authorArndt, Volker
dc.contributor.authorStegmaier, Christa
dc.contributor.authorJustenhoven, Christina
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorBrüning, Thomas
dc.contributor.authorWang-Gohrke, Shan
dc.contributor.authorEilber, Ursula
dc.contributor.authorDörk, Thilo
dc.contributor.authorSchürmann, Peter
dc.contributor.authorBremer, Michael
dc.contributor.authorHillemanns, Peter
dc.contributor.authorBogdanova, Natalia V.
dc.contributor.authorAntonenkova, Natalia N.
dc.contributor.authorRogov, Yuri I.
dc.contributor.authorKarstens, Johann H.
dc.contributor.authorBermisheva, Marina
dc.contributor.authorProkofieva, Darya
dc.contributor.authorKhusnutdinova, Elza
dc.contributor.authorLindblom, Annika
dc.contributor.authorMargolin, Sara
dc.contributor.authorMannermaa, Arto
dc.contributor.authorKataja, Vesa
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorHartikainen, Jaana M
dc.contributor.authorLambrechts, Diether
dc.contributor.authorYesilyurt, Betul T.
dc.contributor.authorFloris, Giuseppe
dc.contributor.authorLeunen, Karin
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorFortuzzi, Stefano
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorCouch, Fergus J
dc.contributor.authorWang, Xianshu
dc.contributor.authorStevens, Kristen
dc.contributor.authorLee, Adam
dc.contributor.authorGiles, Graham G.
dc.contributor.authorBaglietto, Laura
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorMcLean, Catriona
dc.contributor.authorAlnæs, Grethe Grenaker
dc.contributor.authorKristensen, Vessela
dc.contributor.authorBørrensen-Dale, Anne-Lise
dc.contributor.authorJohn, Esther M.
dc.contributor.authorMiron, Alexander
dc.contributor.authorWinqvist, Robert
dc.contributor.authorPylkäs, Katri
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorKauppila, Saila
dc.contributor.authorAndrulis, Irene L.
dc.contributor.authorGlendon, Gord
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorDevilee, Peter
dc.contributor.authorvan Asperen, Christie J.
dc.contributor.authorTollenaar, Rob A.E.M.
dc.contributor.authorSeynaeve, Caroline
dc.contributor.authorFigueroa, Jonine D
dc.contributor.authorGarcia-Closas, Montserrat
dc.contributor.authorBrinton, Louise
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorHooning, Maartje J.
dc.contributor.authorHollestelle, Antoinette
dc.contributor.authorOldenburg, Rogier A.
dc.contributor.authorvan den Ouweland, Ans M.W.
dc.contributor.authorCox, Angela
dc.contributor.authorReed, Malcolm WR
dc.contributor.authorShah, Mitul
dc.contributor.authorJakubowska, Ania
dc.contributor.authorLubinski, Jan
dc.contributor.authorJaworska, Katarzyna
dc.contributor.authorDurda, Katarzyna
dc.contributor.authorJones, Michael
dc.contributor.authorSchoemaker, Minouk
dc.contributor.authorAshworth, Alan
dc.contributor.authorSwerdlow, Anthony
dc.contributor.authorBeesley, Jonathan
dc.contributor.authorChen, Xiaoqing
dc.contributor.authorMuir, Kenneth R
dc.contributor.authorLophatananon, Artitaya
dc.contributor.authorRattanamongkongul, Suthee
dc.contributor.authorChaiwerawattana, Arkom
dc.contributor.authorKang, Daehee
dc.contributor.authorYoo, Keun-Young
dc.contributor.authorNoh, Dong-Young
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorYu, Jyh-Cherng
dc.contributor.authorWu, Pei-Ei
dc.contributor.authorHsiung, Chia-Ni
dc.contributor.authorPerkins, Annie
dc.contributor.authorSwann, Ruth
dc.contributor.authorVelentzis, Louiza
dc.contributor.authorEccles, Diana M
dc.contributor.authorTapper, Will J
dc.contributor.authorGerty, Susan M
dc.contributor.authorGraham, Nikki J
dc.contributor.authorPonder, Bruce A. J.
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorPharoah, Paul D.P.
dc.contributor.authorLathrop, Mark
dc.contributor.authorDunning, Alison M.
dc.contributor.authorRahman, Nazneen
dc.contributor.authorPeto, Julian
dc.contributor.authorEaston, Douglas F
dc.date.accessioned2013-12-12T15:22:31Z
dc.date.issued2013
dc.identifier.citationGhoussaini, Maya, Olivia Fletcher, Kyriaki Michailidou, Clare Turnbull, Marjanka K Schmidt, Ed Dicks, Joe Dennis, et al. 2013. Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nature genetics 44(3): 312-318.en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11370694
dc.description.abstractBreast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ~ 8% of the heritability of the disease. We followed up 72 promising associations from two independent Genome Wide Association Studies (GWAS) in ~70,000 cases and ~68,000 controls from 41 case-control studies and nine breast cancer GWAS. We identified three new breast cancer risk loci on 12p11 (rs10771399; P=2.7 × 10−35), 12q24 (rs1292011; P=4.3×10−19) and 21q21 (rs2823093; P=1.1×10−12). SNP rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) plays a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, while NRIP1 (21q21) encodes an ER co-factor and has a role in the regulation of breast cancer cell growth.en_US
dc.language.isoen_USen_US
dc.relation.isversionofdoi:10.1038/ng.1049en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653403/pdf/en_US
dash.licenseLAA
dc.titleGenome-wide association analysis identifies three new breast cancer susceptibility locien_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNature geneticsen_US
dash.depositing.authorHunter, David J.
dc.date.available2013-12-12T15:22:31Z
dc.identifier.doi10.1038/ng.1049*
dash.authorsorderedfalse
dash.contributor.affiliatedHunter, David
dash.contributor.affiliatedMiron, A


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