Show simple item record

dc.contributor.authorHou, Lifang
dc.contributor.authorZhang, Xiao
dc.contributor.authorDioni, Laura
dc.contributor.authorBarretta, Francesco
dc.contributor.authorDou, Chang
dc.contributor.authorZheng, Yinan
dc.contributor.authorHoxha, Mirjam
dc.contributor.authorBertazzi, Pier Alberto
dc.contributor.authorSchwartz, Joel David
dc.contributor.authorWu, Shanshan
dc.contributor.authorWang, Sheng
dc.contributor.authorBaccarelli, Andrea
dc.date.accessioned2013-12-13T17:36:56Z
dc.date.issued2013
dc.identifier.citationHou, Lifang, Xiao Zhang, Laura Dioni, Francesco Barretta, Chang Dou, Yinan Zheng, Mirjam Hoxha, et al. 2013. Inhalable particulate matter and mitochondrial dna copy number in highly exposed individuals in beijing, china: a repeated-measure study. Particle and Fibre Toxicology 10: 17.en_US
dc.identifier.issn1743-8977en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11375877
dc.description.abstractBackground: Mitochondria are both a sensitive target and a primary source of oxidative stress, a key pathway of air particulate matter (PM)-associated diseases. Mitochondrial DNA copy number (MtDNAcn) is a marker of mitochondrial damage and malfunctioning. We evaluated whether ambient PM exposure affects MtDNAcn in a highly-exposed population in Beijing, China. Methods: The Beijing Truck Driver Air Pollution Study was conducted shortly before the 2008 Beijing Olympic Games (June 15-July 27, 2008) and included 60 truck drivers and 60 office workers. Personal PM2.5 and elemental carbon (EC, a tracer of traffic particles) were measured during work hours using portable monitors. Post-work blood samples were obtained on two different days. Ambient PM10 was averaged from 27 monitoring stations in Beijing. Blood MtDNAcn was determined by real-time PCR and examined in association with particle levels using mixed-effect models. Results: In all participants combined, MtDNAcn was negatively associated with personal EC level measured during work hours (β=−0.059, 95% CI: -0.011; -0.0006, p=0.03); and 5-day (β=−0.017, 95% CI: -0.029;-0.005, p=0.01) and 8-day average ambient PM10 (β=−0.008, 95% CI: -0.043; -0.008, p=0.004) after adjusting for possible confounding factors, including study groups. MtDNAcn was also negatively associated among office workers with EC (β=−0.012, 95% CI: -0.022;-0.002, p=0.02) and 8-day average ambient PM10 (β=−0.030, 95% CI: -0.051;-0.008, p=0.007). Conclusions: We observed decreased blood MtDNAcn in association with increased exposure to EC during work hours and recent ambient PM10 exposure. Our results suggest that MtDNAcn may be influenced by particle exposures. Further studies are required to determine the roles of MtDNAcn in the etiology of particle-related diseases.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1743-8977-10-17en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649952/pdf/en_US
dash.licenseLAA
dc.subjectChinaen_US
dc.subjectMitochondrial DNAen_US
dc.subjectMitochondrial DNA copy numberen_US
dc.subjectParticulate matteren_US
dc.subjectTraffic pollutionen_US
dc.titleInhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalParticle and Fibre Toxicologyen_US
dash.depositing.authorSchwartz, Joel David
dc.date.available2013-12-13T17:36:56Z
dc.identifier.doi10.1186/1743-8977-10-17*
dash.authorsorderedfalse
dash.contributor.affiliatedSchwartz, Joel
dash.contributor.affiliatedBaccarelli, Andrea


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record