Browsing Harvard School of Dental Medicine by Title
Now showing items 16-34 of 34
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Halofuginone Prevents the Progression of Osteoarthritis
(2015-07-02)Background: Halofuginone (HF) is a natural product that has been shown to have therapeutic benefits in a variety of pathologic conditions, from cancer to autoimmune diseases. These beneficial effects are mainly through ... -
Immune Reconstitution of B Cells Following Allogeneic Hematopoietic Cell Transplantation
(2015-07-02)Objectives: Graft versus host disease (GVHD), infections and disease relapse continue to be major complications of allogeneic hematopoietic cell transplantation (HCT). B cell abnormalities have been associated with these ... -
Immunomodulation of Macrophages in Periapical Wound Healing
(2016-08-16)Background: A periapical lesion is an infection-induced inflammation around the apex of the tooth caused by bacterial invasion and ultimately results in the destruction of bone in the area. To date, the relationship between ... -
Impact of Resolvin E1 on Experimental Periodontitis and Periodontal Biofilm
(2015-07-02)Objective: The goal of this project was to determine the impact of local inflammation on changes in the subgingival biofilm composition in ligature-induced periodontitis in rats using the specialized pro-resolving mediator ... -
Longitudinal Clinical Outcomes and Cost- Effectiveness Evaluation of a Comprehensive School- Based Dental Prevention Program – ForsythKids
(2016-08-16)We aimed to evaluate longitudinal clinical outcomes and cost-effectiveness of a comprehensive school-based caries prevention program, ForsythKids. In collaboration with the Massachusetts Department of Health, we solicited ... -
The Possible Roles of CD73 and Adenosine in the Osteoimmunological Bone Resorption of Periradicular Periodontitis
(2016-08-16)Introduction: Periradicular periodontitis is an inflammatory disease caused by perpetual microbial infection in the root canal system which, if left untreated, results in the destruction of tooth supporting tissues. Tenacious ... -
Pro-Resolving Maresins in Inflammation: New Pathway and Mechanisms With Oral Pathogens
(2015-07-02)Objectives The aim of this thesis was to study the biosynthesis of Maresin 1 (MaR1) in human macrophage and to investigate the potential defect of this pathway in patients with localized aggressive periodontitis as well ... -
Resolution of Inflammation in Type 2 Diabetes
(2016-08-16)Unresolved inflammation is a key factor linking metabolic dysregulation and the immune system in type 2 diabetes. Successful regulation of acute inflammation requires biosynthesis of specialized pro-resolving lipid ... -
Role of Sfrp4, a Wnt Antagonist, in Bone Repair and Regeneration
(2021-05-19)Sfrp4 (Secreted Frizzled Receptor Protein 4) serves as a decoy receptor for Wnts and differently from sclerostin (Sost) that blocks canonical (c)Wnt signaling, it suppresses cWnt and non-cWnt cascades. Loss of function ... -
Role of the Transcription Factor Zinc Finger Protein 521 on Runx2 Acetylation
(2015-07-02)Runx2 is a transcription factor that has a crucial role in the development of bone; haploinsufficiency of Runx2 leads to the autosomal-dominant disorder, cleidocranial dysplasia (CCD) characterized by various skeletal ... -
Saturation of the Biological Response to Orthodontic Forces and Its Effect on the Rate of Tooth Movement
(2016-04-11)Objectives: The objectives of this research are to investigate the biological response of the body to different magnitude of force, and to investigate if the response varies among individuals. Therefore this research has ... -
Short Sleep Duration as a Risk Factor for Obesity and Gingivitis in Kuwaiti Children: A Longitudinal Multilevel Analysis
(2016-08-16)Objectives: It has been shown that inadequate sleep has negative effect on health including obesity, diabetes, and cardiovascular diseases. Current evidence showed that little sleep impairs immunity, promotes systemic ... -
Socio-Economic Inequalities in Dental Care Utilization Among the U.S. Population: A Study of Trends From 2010 to 2019
(2021-06-01)Objectives for aim1 a and aim1 b: Medicaid expansion under the Affordable Care Act (ACA) has tremendously improved the utilization of dental services among children under 19 years of age.9 Despite this progress, there are ... -
Substance Use and Mental Health Conditions Among US Active-Duty Military Personnel: Prevalence and Associated Factors
(2023-07-27)Objective: To assess the relationship between three mental health conditions (post-traumatic stress disorder [PTSD], generalized anxiety disorder [GAD], and depressive symptoms), and cigarette smoking or marijuana use. We ... -
The role of ATF-3 in physiologic and neoplastic cellular proliferation
(2021-05-19)Activating transcription factor 3 (ATF-3), a cyclic AMP-dependent transcription factor that is encoded by the ATF-3 gene, plays a potential regulatory role in physiologic and pathologic cell proliferation including wound ... -
The Role of Sfrp4 in Alveolar Bone and Incisor Tooth Extraction Socket Healing
(2021-05-19)Objectives: The purpose of this study is to explore the effects of Sfrp4 deletion on alveolar bone and healing of incisor tooth extraction sockets. Introduction: There are many genetic and development bone diseases that ... -
Topical Clonazepam and Placebo Effect in Burning Mouth Syndrome
(2016-08-16)Burning mouth syndrome (BMS) is a chronic pain condition reported to affect up to 7.9% of the general population, with associated detrimental impact on patients’ quality of life. Currently employed treatment regimens follow ... -
Tunnel Attachments Paired with Invisalign® for Orthodontic Leveling and Aligning – A Randomized Controlled Clinical Trial
(2023-07-27)Background: Clear aligner therapy has yet to overcome limitations in achieving certain orthodontic tooth movements, more specifically rotations of conical teeth, vertical movements, correcting angulation and inclination. ... -
A Two-Pronged Approach to Understanding Quality and Safety Events at the Dental Office
(2016-08-16)ABSTRACT Objectives: Owing to the limited number and scope of studies in dentistry regarding quality and patient safety, the overarching goal of this thesis was to understand the nature and occurrence of quality and ...