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Role of the Transcription Factor Zinc Finger Protein 521 on Runx2 Acetylation
Runx2 is a transcription factor that has a crucial role in the development of bone; haploinsufficiency of Runx2 leads to the autosomal-dominant disorder, cleidocranial dysplasia (CCD) characterized by various skeletal ...
Halofuginone Prevents the Progression of Osteoarthritis
Background: Halofuginone (HF) is a natural product that has been shown to have therapeutic benefits in a variety of pathologic conditions, from cancer to autoimmune diseases. These beneficial effects are mainly through ...
Experimental Evaluation of Discoid Domain Receptor 2 as an Ideal Target for Development of Disease-Modifying Osteoarthritis Drugs
Abstract: Osteoarthritis (OA) affects 250 million people worldwide. Currently, no targets for disease-modifying osteoarthritis drugs exist. Matrix metalloproteinase-13 (MMP-13) would make it an ideal target; however, its ...
Saturation of the Biological Response to Orthodontic Forces and Its Effect on the Rate of Tooth Movement
Objectives: The objectives of this research are to investigate the biological response of the body to different magnitude of force, and to investigate if the response varies among individuals. Therefore this research has ...
Development of Novel Anti-DC-STAMP Monoclonal Antibody Targeting Osteolytic Periodontal Lesion
Background: Dendritic cell-specific transmembrane protein (DC-STAMP) plays a key role in the induction of osteoclast (OC) cell fusion. This conclusion is supported by evidence showing that osteoclast cell fusion is diminished, ...