Browsing HSDM Theses and Dissertations by Title
Now showing items 5-24 of 34
-
Biologic Significance of 5-Hydroxymethylcytosine Expression in Oral Mucosal Epithelial Dysplasia and Oral Squamous Cell Carcinoma
(2016-03-03)Current modeling postulates that the development of cancer is driven by the accumulation of genetic mutations and epigenetic modifications, resulting in a clonal population of cells with deregulated growth characteristics. ... -
Cellular Response to Expansion and Compression Forces in Mouse Midpalatal Suture and Surrounding Structures
(2016-08-16)Objectives – To investigate the anatomy of the mouse palate, the midpalatal suture, and the cellular characteristics in the sutures before and immediately after midpalatal suture expansion, and as well as, to study the ... -
A Comparison of Zirconia CAD/CAM to Conventionally Fabricated Single Implant Restorations in the Esthetic Zone
(2015-07-02)Objective: This project aimed to determine whether single tooth implant restorations fabricated with CAD/CAM zirconia abutments/porcelain fused to zirconia crowns reveal different biological and esthetic outcomes compared ... -
A Comprehensive Assessment of Soft Tissue Esthetics
(2015-07-02)This thesis investigated the efficacy of two techniques, digital spectrophotometry and narrow-band endoscopy, in observing and describing gingival tissue in a patient population. The efficacy of existing gingival restorative ... -
Comprehensive Optical Assessment of Peri-Implant Mucosa
(2015-07-02)Esthetic outcomes with implants begin with proper implant placement, but the predictability of the peri-implant esthetic outcome is also affected by patient’s pre-existing or reconstructed local tissue. An unpleasant optical ... -
Deletion of the Parathyroid Hormone Receptor in Marrow Adipose Lineage Precursors (MALPs) Prevents Their Negative Regulation of Skeletal Homeostasis
(2021-05-19)Background and objectives: Parathyroid hormone (PTH) is essential for skeletal homeostasis and PTH[1-34] (teriparatide) is used to treat severe osteoporosis, medication-related osteonecrosis of the jaws, and enhance implant ... -
Determination of Attitudes and Knowledge about Patient Perceptions of Expanded Roles and Responsibilities for Dentists as "Oral Physicians"
The overall objective of this study was to determine knowledge and attitudes of dentists and patients about dentists’ expanding their roles in preventive primary health care as oral physicians. There are hundreds of genetic ... -
Development of Novel Anti-DC-STAMP Monoclonal Antibody Targeting Osteolytic Periodontal Lesion
(2016-08-16)Background: Dendritic cell-specific transmembrane protein (DC-STAMP) plays a key role in the induction of osteoclast (OC) cell fusion. This conclusion is supported by evidence showing that osteoclast cell fusion is diminished, ... -
Electrokinetic Flow Assisted Dentin Disinfection
(2021-07-19)Background: The bacterial persistence within the root canals and dentinal tubules in infected and necrotic pulp poses a serious health risk, with reinfection of the endodontically treated tooth being one of the main problems ... -
Evaluation of αLphav Integrin Role in Mouse Model Induced Periapical Periodontitis
(2016-08-16)Abstract: Background: alphav (av) integrin is the most common integrin alpha subunit, it is expressed in different cells and involved in many cellular process including adhesion, migration, survival and growth factor ... -
Experimental Evaluation of Discoid Domain Receptor 2 as an Ideal Target for Development of Disease-Modifying Osteoarthritis Drugs
(2015-07-02)Abstract: Osteoarthritis (OA) affects 250 million people worldwide. Currently, no targets for disease-modifying osteoarthritis drugs exist. Matrix metalloproteinase-13 (MMP-13) would make it an ideal target; however, its ... -
Halofuginone Prevents the Progression of Osteoarthritis
(2015-07-02)Background: Halofuginone (HF) is a natural product that has been shown to have therapeutic benefits in a variety of pathologic conditions, from cancer to autoimmune diseases. These beneficial effects are mainly through ... -
Immune Reconstitution of B Cells Following Allogeneic Hematopoietic Cell Transplantation
(2015-07-02)Objectives: Graft versus host disease (GVHD), infections and disease relapse continue to be major complications of allogeneic hematopoietic cell transplantation (HCT). B cell abnormalities have been associated with these ... -
Immunomodulation of Macrophages in Periapical Wound Healing
(2016-08-16)Background: A periapical lesion is an infection-induced inflammation around the apex of the tooth caused by bacterial invasion and ultimately results in the destruction of bone in the area. To date, the relationship between ... -
Impact of Resolvin E1 on Experimental Periodontitis and Periodontal Biofilm
(2015-07-02)Objective: The goal of this project was to determine the impact of local inflammation on changes in the subgingival biofilm composition in ligature-induced periodontitis in rats using the specialized pro-resolving mediator ... -
Longitudinal Clinical Outcomes and Cost- Effectiveness Evaluation of a Comprehensive School- Based Dental Prevention Program – ForsythKids
(2016-08-16)We aimed to evaluate longitudinal clinical outcomes and cost-effectiveness of a comprehensive school-based caries prevention program, ForsythKids. In collaboration with the Massachusetts Department of Health, we solicited ... -
The Possible Roles of CD73 and Adenosine in the Osteoimmunological Bone Resorption of Periradicular Periodontitis
(2016-08-16)Introduction: Periradicular periodontitis is an inflammatory disease caused by perpetual microbial infection in the root canal system which, if left untreated, results in the destruction of tooth supporting tissues. Tenacious ... -
Pro-Resolving Maresins in Inflammation: New Pathway and Mechanisms With Oral Pathogens
(2015-07-02)Objectives The aim of this thesis was to study the biosynthesis of Maresin 1 (MaR1) in human macrophage and to investigate the potential defect of this pathway in patients with localized aggressive periodontitis as well ... -
Resolution of Inflammation in Type 2 Diabetes
(2016-08-16)Unresolved inflammation is a key factor linking metabolic dysregulation and the immune system in type 2 diabetes. Successful regulation of acute inflammation requires biosynthesis of specialized pro-resolving lipid ... -
Role of Sfrp4, a Wnt Antagonist, in Bone Repair and Regeneration
(2021-05-19)Sfrp4 (Secreted Frizzled Receptor Protein 4) serves as a decoy receptor for Wnts and differently from sclerostin (Sost) that blocks canonical (c)Wnt signaling, it suppresses cWnt and non-cWnt cascades. Loss of function ...