Browsing HSDM Theses and Dissertations by Keyword "Dentistry"
Now showing items 1-8 of 8
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A Method to Trace Porphyromonas gingivalis Within Periodontal Ligament in 3D
(2021-05-07)Background and Objective: Periodontitis is an inflammatory disease caused by bacterial dysbiosis that leads to tooth support loss and eventually, loss of tooth. There have been studies using micro-CT, histology, and electron ... -
A Novel Injectable Hydrogel Incorporating Lipoxin for Treatment of Inflammation-mediated Bone Resorption
(2021-07-19)Increased inflammation can disturb bone homeostasis leading to increased osteoclastogenesis and bone resorption. Studies have demonstrated that specialized pro-resolving lipid mediators such as lipoxins, can counteract ... -
Assessing the Neurotoxicity of Endodontic Sealers
(2021-08-12)Many times the relationship between dental materials and clinical outcomes is poorly understood because so little is known about the biocompatibility of materials and the biological pathways they may affect. In endodontics, ... -
Role of Sfrp4, a Wnt Antagonist, in Bone Repair and Regeneration
(2021-05-19)Sfrp4 (Secreted Frizzled Receptor Protein 4) serves as a decoy receptor for Wnts and differently from sclerostin (Sost) that blocks canonical (c)Wnt signaling, it suppresses cWnt and non-cWnt cascades. Loss of function ... -
Socio-Economic Inequalities in Dental Care Utilization Among the U.S. Population: A Study of Trends From 2010 to 2019
(2021-06-01)Objectives for aim1 a and aim1 b: Medicaid expansion under the Affordable Care Act (ACA) has tremendously improved the utilization of dental services among children under 19 years of age.9 Despite this progress, there are ... -
The role of ATF-3 in physiologic and neoplastic cellular proliferation
(2021-05-19)Activating transcription factor 3 (ATF-3), a cyclic AMP-dependent transcription factor that is encoded by the ATF-3 gene, plays a potential regulatory role in physiologic and pathologic cell proliferation including wound ... -
The Role of Sfrp4 in Alveolar Bone and Incisor Tooth Extraction Socket Healing
(2021-05-19)Objectives: The purpose of this study is to explore the effects of Sfrp4 deletion on alveolar bone and healing of incisor tooth extraction sockets. Introduction: There are many genetic and development bone diseases that ... -
Tunnel Attachments Paired with Invisalign® for Orthodontic Leveling and Aligning – A Randomized Controlled Clinical Trial
(2023-07-27)Background: Clear aligner therapy has yet to overcome limitations in achieving certain orthodontic tooth movements, more specifically rotations of conical teeth, vertical movements, correcting angulation and inclination. ...