Browsing HMS Theses and Dissertations by Title
Now showing items 21-40 of 506
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Amygdalar Activity Measured Using FDG-PET/CT at Head and Neck Cancer Staging Independently Predicts Survival and Cardiovascular Outcomes: A Retrospective Cohort Study
(2019-06-03)Background Chronic stress associates with higher mortality among individuals with cancer; however, the mechanisms underlying this association remain incompletely understood. Quantification of amygdalar metabolic activity ... -
Analysis of Monocusp Valve Design for Reconstruction of Right Ventricular Outflow Tract in Tetralogy of Fallot: An In Vitro Study
(2022-05-10)Tetralogy of Fallot (TOF) is one of the most common cyanotic congenital heart diseases (CHD), which accounts for approximately 10 percent of all CHD1, requiring intervention in the first year of life. Cardiac surgeons ... -
Analysis of Myeloid Derived Suppressor Cells and the Role of Inducible Nitric Oxide Synthase in Renal Transplantation Across MHC Mismatched Mice
(2016-05-24)Despite recent advances in immunology and post-operative care, transplant recipients continue to face major complications. This is due to immune-mediated destruction of graft tissue and drug toxicity caused by chronic ... -
Analysis of Report Addenda as a Novel Approach to Characterization and Quantification of Errors in Diagnostic Radiology
(2015-06-08)Diagnostic errors are common in radiology and can have a significant negative impact on patient care. Identifying the types of errors that occur can improve our understanding of the root causes and suggest pathways for ... -
Analysis of the National Surgical Quality Improvement Program Database in 19,100 Patients Undergoing Implant-Based Breast Reconstruction: Complication Rates With Acellular Dermal Matrix
(2015-06-04)Background: The use of acellular dermal matrices has become increasingly popular in immediate and delayed tissue expander/implant–based breast reconstruction. However, it is unclear whether their use is associated with ... -
Anti-Galectin-3 and Anti-Cytokine Antibodies in IgG4-Related Disease
(2018-05-04)IgG4-Related Disease (IgG4-RD) is a chronic, immune-mediated disease that typically manifests as tumor-like enlargement of various organs. Prior work suggests a role for plasmablasts and CD4+ cytotoxic T lymphocytes (CD4+ ... -
Antigens in the Pathogenesis of Immunoglobulin G4 - Related Disease
(2017-06-07)Immunoglobulin G4-Related Disease (IgG4-RD) is a chronic, fibroinflammatory disorder capable of affecting every organ system. Under the umbrella of IgG4-RD, many poorly characterized eponymous disorders such as Kuttner’s ... -
The Apathy Evaluation Scale: A Comparison of Subject, Informant, and Clinician Report in Cognitively Normal Elderly and Mild Cognitive Impairment
(2015-06-04)Background: Apathy is a common symptom in Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI). The Apathy Evaluation Scale (AES) is a promising tool for measuring apathy in early AD. Objective: To compare ... -
Approaches to improve the diagnosis and treatment of traumatic neuropathic pain
(2023-05-11)"The most terrible of all tortures which a nerve wound may inflict.” Silas W. Mitchell, a neurologist during the American Civil War, stated in his book Injuries of Nerves and their Consequence. (1) One hundred and fifty ... -
AREG and IFNG Define Subsets of γδ T Cells with Distinct Functional Properties in Human Cancer
(2023-05-10)γδ T cells are a subset of innate T cells. They activate in minutes - rather than days - after stimulus and play a role in immune surveillance and anti-tumor responses. In general, the presence of γδ T cells in tumors is ... -
ASSESSING BARRIERS OF CONTRACEPTIVE UPTAKE AMONG ADOLESCENT GIRLS IN A RURAL DISTRICT OF MALAWI
(2021-06-25)Background: The unmet need for family planning for unmarried adolescents in Malawi remains high despite efforts to improve provision, leading to a high rate of adolescent pregnancies. In Neno District, there is a 52% unmet ... -
Assessing the Effect of Epigenetic Dysregulation on Oncogenesis and Immunocompetence in a Mouse Model
(2018-05-15)While there is a clear link between increasing mammalian age and alteration in baseline gene expression in somatic cells, the causality of these changes, how they affect the aging process itself, and their effect on ... -
Assessing the effectiveness of gamified and non-gamified online clinical laboratory educational modules for medical students
(2023-07-10)Collecting points. Earning rewards. These are features one would expect to find within an entertaining game. Gamification incorporates these design elements into non-game settings in the hopes of harnessing the engaging ... -
Assessment of Barriers of Contraceptive Use in Rural Burundi: A Mixed Methods Study
(2014-10-15)Burundi’s high maternal and child mortality is caused in part by the high fertility rate, prompted by low rate of contraceptive use. Available sources report a contraceptive use of 18% among married women, but this excludes ... -
Assessment of Perioperative Morbidity for Radical Cystectomy in Elderly Patients
(2015-06-08)OBJECTIVE: To assess the perioperative morbidity and impact of comorbidities in elderl patients undergoing radical cystectomy (RC) for bladder cancer. PATIENTS AND METHODS: A retrospective study of 52 patients greater ... -
Assessment of Priority Non-Communicable Diseases and Injuries (NCDI) Interventions and Human Resourcing at Selected Health Facilities in Four Regions of Ethiopia
(2021-06-25)Background and Rationale: Non-communicable diseases and injuries (NCDIs) are now major causes of mortality and morbidity globally. The Ethiopian NCDI Commission launched in 2018, estimated the burden of NCDIs as the causes ... -
The Association Between Patient Complexity and Primary Care Visit Length and Composition
(2016-05-17)Importance: Our research examines the duration and content of primary care visits with a focus on whether visit length or composition differs for highly complex patients as compared to non-complex patients. This comparison ... -
Association of Clinical Features With Incidental Findings From Exome Sequencing in 3,223 African Americans
(2015-09-29)Importance. The American College of Medical Genetics and Genomics recommends informing individuals who carry mutations in a set of Mendelian disease genes that might require clinical action regardless of genetic testing ... -
Association of GLP1R polymorphisms with the incretin response: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH)
(2021-05-14)ABSTRACT PAPER 1 Objective: Polymorphisms in the gene encoding the glucagon-like peptide-1 receptor (GLP1R) are associated with type 2 diabetes, fasting glucose, and postprandial glucose, but their effects on incretin ... -
Associations Between Funding Source and Results of Cost Effectiveness Analyses of Drugs Used in Breast Cancer
(2015-05-13)Background: Cost effectiveness studies are increasingly included in the regulatory decisions of many countries and in formulary decisions in the United States. Pharmaceutical company sponsorship of economic analyses of ...