Browsing HMS Theses and Dissertations by Title
Now showing items 1-20 of 506
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24H FOLLOW-UP CT| METFORMIN PRETREATMENT: TWO REFLECTIONS FROM CLINICAL STROKE PRACTICE
(2023-05-11)Acute ischemic stroke is a serious medical emergency caused by the blockage of blood flow to the brain. With an estimated 15 million new cases each year, it is a leading cause of morbidity and mortality worldwide. The ... -
A Combined Mastery Learning and Flipped-Classroom Approach: The Effect on Self-Assessment of Leadership Skills
(2022-05-12)Abstract Strong leadership is associated with better performance of individuals, teams, and organizations. This project aimed to determine whether a flipped-classroom and mastery-learning curriculum is associated with ... -
A network meta-analysis and whole-exome analysis of chronic lymphocytic leukemia patients treated with ibrutinib and chlorambucil
(2022-05-12)Abstract (project 1) Background Both ibrutinib and chlorambucil, used alone or in combination, have been used for first-line treatment for CLL. However, a comprehensive comparison among different CLL therapies, including ... -
A NOVEL BIOMARKER IN ACUTE HEART FAILURE AND OBESITY PARADOX IN ACUTE MEDICAL ILLNESS
(2021-06-23)Each year, approximately 8 million patients in the United States and 12 million patients in the European countries are hospitalized for acute medical illnesses such as heart failure, pneumonia, and stroke. VTE is an important ... -
A Novel Dual NK Cell CAR Targeting CTLA-4 to Induce Regulatory T Cell Depletion in Head and Neck Cancer Microenvironment
(2023-05-10)Head and neck cancer (HNC) is one of the most common cancers in the US affecting 66,470 people in 2022. Despite advances in chemotherapy, radiation therapy, and surgery, about 50% of patients still develop recurrent/metastatic ... -
A PHENOMENOLOGICAL APPROACH TO EXPLORING THE EXPERIENCE AND TRAINING OF HMS AFFILIATED ANESTHESIA RESIDENTS THAT FACILITATE DEVELOPMENT OF TEACHING SKILLS
(2021-09-20)Background: The majority of anesthesia teaching and training occurs in a one-on-one manner. Residents are often first-line teachers to medical students and junior trainees from other specialties. While their skills as ... -
a Practical Guide to Ethical Decision-Making Regarding Drug Coverage for Rare Diseases: Case Study of Nusinersen Therapy for Spinal Muscular Atrophy
(2019-05-06)Nusinersen for the treatment of Spinal Muscular Atrophy was among the first definitive treatments for neurodegenerative conditions to come to market as of 2016. The drug’s rapid U.S. governmental approval came on the heels ... -
A QUALITATIVE STUDY OF COLLABORATIVE RELATIONSHIPS ENABLING PHARMACEUTICAL CLINICAL TRIALS FOR ALZHEIMER’S DISEASE IN LOW- AND MIDDLE-INCOME COUNTRIES
(2021-06-25)With no cure or disease-modifying treatment for Alzheimer’s Disease (A.D.) and high-profile drug failures in recent clinical trials, there remains a global commitment to advancing dementia research and therapeutic innovation. ... -
A Surgical Approach to Induce Local Reversal of Blood Flow to Assess Plasticity of Segmented Endothelium in the Mouse Ear
(2018-05-16)I aim to test the hypothesis that arteriolar endothelial cells will behave as venular endothelial cells and mediate leukocyte rolling following local reversal of blood flow. In live models, this hypothesized reprogramming ... -
AAV TRANSDUCTION TRACING IN HEMATOPOIETIC CELLS BY TARGETED SCARRING OF GENOMIC SAFE HARBORS
(2023-05-10)AAV is a potent and broadly used gene delivery platform with potential applications to treat many genetic diseases, including incurable diseases of hematopoietic cells and the immune system. As this viral vector becomes ... -
The Acceptability and Impact of a Weekly Text-Messaging Program to Support HIV Treatment Adherence in KwaZulu-Natal, South Africa
(2017-05-12)Introduction: In randomized controlled trials, short message service (SMS) programs have improved adherence to HIV antiretroviral therapy (ART). In response, the World Health Organization recommended use of SMS programs ... -
Adaptive Expertise in Plastic Surgery: The Plastic Surgeon Experience of Developing, Maintaining and Teaching Adaptive Expertise
(2024-01-17)Background: Plastic surgery is a surgical field defined not by a particular anatomical domain, age group, nor pathology. Instead, it is characterized by problem-solving and innovation. Adaptive expertise, described initially ... -
Adherence to Antiretroviral Therapy, Polypharmacy, and Virologic Failure in Women with HIV in the United States: Retrospective Cohort Analysis
(2022-05-10)Background: Women with HIV (WHIV) in the United States face many challenges with adherence to antiretroviral drugs and suboptimal adherence often leads to virologic failure. Objectives: The main aim of this study was ... -
Adult-Oriented Health Insurance Reform and Children's Health Insurance: the Massachusetts Experience and Implications for the Affordable Care Act
(2016-05-17)BACKGROUND: The Massachusetts health reform and the Affordable Care Act (ACA) were focused on adults, but have the potential to reduce uninsurance and increase access to affordable health care for children. Little is known ... -
Adverse Events Associated with Sedative and Anesthetic Drugs in Pediatric Patients
(2023-05-11)OVERVIEW The use of sedatives and anesthetics in pediatric critical care settings and operating rooms is inevitable. Sedation is required in critically ill pediatric patients to aid ventilation and decrease anxiety and ... -
Age and Sex Dependent Variations in Knee Anatomy During Skeletal Maturation in Children and Adolescents
(2016-05-18)Knee joint is the most common site of injury in children and adolescents and accounts for up to 60% of all sports-related injuries in this population. Ruptures of the anterior cruciate ligament (ACL) are among the most ... -
Alcohol Consumption and Risk of Heart Failure
(2015-05-20)Aim: Alcohol is a known cardiac toxin and heavy consumption can lead to heart failure (HF). However, the relationship between moderate alcohol consumption and risk for HF, in either men or women, remains unclear. Methods ... -
Alcohol Intake and Risk of Incident Melanoma
(2015-06-08)Alcohol consumption is associated with increased risk of numerous cancers, but has not been definitively associated with risk of melanoma. We used prospectively gathered data from three large cohorts to investigate whether ... -
Ambient Fine Particulate Matter, Outdoor Temperature and Risk of Metabolic Syndrome
(2016-05-17)Ambient air pollution and temperature have been linked with cardiovascular morbidity and mortality. Metabolic syndrome and its components—abdominal obesity, elevated fasting blood glucose, low high-density lipoprotein ... -
Ambient Temperature and Sudden Infant Death Syndrome in the United States
(2019-05-06)Background: Sudden infant death syndrome (SIDS) is a leading cause of infant mortality in the United States. While thermal stress is implicated in many risk factors for SIDS, the association between ambient temperature and ...