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Alcohol Consumption and Risk of Heart Failure
(2015-05-20)
Aim: Alcohol is a known cardiac toxin and heavy consumption can lead to heart failure (HF). However, the relationship between moderate alcohol consumption and risk for HF, in either men or women, remains unclear.
Methods ...
FRS2 Is an Oncogene in High Grade Ovarian Cancer
(2015-05-13)
Ovarian cancer is the most common cause of gynecologic cancer death in the United States. Despite aggressive surgical cytoreduction and chemotherapy, ovarian cancer remains one of the most lethal cancer types due to advanced ...
Nanoparticle-Enhanced Near Infrared Fluorescence Imaging of Atheroma Detects Thrombosis-Prone Plaques Prior to Rupture
(2015-05-13)
Introduction: Acute coronary syndromes - including unstable angina, acute myocardial infarction and sudden death - are primarily due to sudden luminal thrombosis from disruption of an atherosclerotic plaque. It has been ...
Outcomes of Laparotomy at a Large Referral Center in Rwanda
(2015-05-13)
Background: A large burden of surgical disease is found in low- to middle-income countries, but only 3.5% of the 234 million major operative procedures performed annually in LMICs due to many challenges. Rwanda faces similar ...
Regulation of Chromatin Remodeling: Linker DNA and Histones
(2015-05-13)
ATP-dependent chromatin remodeling enzymes (remodelers) regulate access to genomic DNA by reading epigenetic marks such as histone modifications and using the energy of ATP hydrolysis to assemble, reposition, disassemble, ...
Epigenetic Dysregulation in Cutaneous Malignant Melanoma: Advancing Approaches to Diagnosis, Prognosis, and Therapeutic Targeting
(2015-05-13)
BACKGROUND: Evidence is rapidly accumulating that epigenetic mechanisms, including DNA methylation and demethylation, histone modifications, and non-coding RNAs, may play a central role in the pathobiology of melanoma. ...
Neural Circuit Mechanisms Underlying the Exacerbation of Alzheimer’s Disease by Chronic Stress
(2015-05-13)
Both epidemiological and animal studies have demonstrated a strong association between Alzheimer’s disease (AD), neuropsychiatric symptoms such as depression and anxiety, and chronic psychological stress. The neurophysiological ...
Multicenter Phase IB/II Study of AdV-Tk, a Gene-Mediated Cytotoxic Immunotherapy, Adjuvant to Surgical Resection for Patients With Newly Diagnosed High Grade Glioma
(2015-05-13)
Purpose: The prognosis for malignant gliomas is poor, and overall survival remains less than 15 months despite improved diagnostic and treatment techniques, underscoring the need for novel therapeutic options. This ...
Use of PD-1, CD1a, and S-100 in Differentiating Pseudolymphomatous Folliculitis and Indolent Primary Cutaneous B-Cell Lymphomas
(2015-05-13)
Background: Pseudolymphomatous folliculitis (PLF) is a non-neoplastic lymphoid proliferation that clinically and histopathologically mimics primary cutaneous extranodal marginal zone lymphoma of mucosa-associated lymphoid ...
Multi-Unit Activity in the Human Cortex as a Predictor of Seizure Onset
(2015-05-13)
Epilepsy is a neurological disorder affecting 50 million people worldwide. It consists of a large number of syndromes, all of which are characterized by a predisposition to recurrent, unprovoked seizures, while differing ...